Barman Snigdha Roy, Khan Imran, Chatterjee Subhodeep, Saha Subhajit, Choi Dukhyun, Lee Sangmin, Lin Zong-Hong
Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan.
Institute of NanoEngineering and Microsystems, National Tsing Hua University, Hsinchu 30013, Taiwan.
J Food Drug Anal. 2020 Dec 15;28(4):595-621. doi: 10.38212/2224-6614.1239.
Digital microfluidic (DMF) platforms have contributed immensely to the development of multifunctional lab-on-chip systems for performing complete sets of biological and analytical assays. Electrowetting-on-dielectric (EWOD) technology, due to its outstanding flexibility and integrability, has emerged as a promising candidate for such lab-on-chip applications. Triggered by an electrical stimulus, EWOD devices allow precise manipulation of single droplets along the designed electrode arrays without employing external pumps and valves, thereby enhancing the miniaturization and portability of the system towards transcending important laboratory assays in resource-limited settings. In recent years, the simple fabrication process and reprogrammable architecture of EWOD chips have led to their widespread applications in food safety analysis. Various EWOD devices have been developed for the quantitative monitoring of analytes such as food-borne pathogens, heavy metal ions, vitamins, and antioxidants, which are significant in food samples. In this paper, we reviewed the advances and developments in the design of EWOD systems for performing versatile functions starting from sample preparation to sample detection, enabling rapid and high-throughput food analysis.
数字微流控（DMF）平台为多功能芯片实验室系统的发展做出了巨大贡献，该系统可用于执行全套生物和分析检测。介电电泳（EWOD）技术因其出色的灵活性和可集成性，已成为此类芯片实验室应用的一个有前途的候选技术。在电刺激的触发下，EWOD设备无需使用外部泵和阀门，就能沿着设计好的电极阵列精确操控单个液滴，从而提高了系统的小型化和便携性，以实现在资源有限的环境中超越重要的实验室检测。近年来，EWOD芯片简单的制造工艺和可重新编程的架构使其在食品安全分析中得到了广泛应用。已开发出各种EWOD设备，用于对食品样本中重要的分析物进行定量监测，如食源性病原体、重金属离子、维生素和抗氧化剂。在本文中，我们综述了EWOD系统在设计方面的进展和发展，该系统具有从样品制备到样品检测的多种功能，能够实现快速、高通量的食品分析。
