Spencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA.
OcuSciences Inc, Ann Arbor, MI.
J Glaucoma. 2022 Aug 1;31(8):634-638. doi: 10.1097/IJG.0000000000002066. Epub 2022 Jun 13.
Short-term use of the Balance Goggles System (BGS) in glaucoma patients was not associated with the observable changes in conventional ocular coherence tomography (OCT) imaging, but metabolic imaging using peripapillary flavoprotein fluorescence (FPF) may represent a useful adjuctive investigation.
To determine whether the intraocular pressure (IOP)-lowering effects of the BGS are accompanied by changes in retinal thickness measured by OCT, retinal vascular density measured by ocular coherence tomography-angiography (OCTA), or novel peripapillary metabolic profiling using FPF measured by a fundus camera.
Prospective comparative case-series.
Eight eyes from 8 patients with open angle glaucoma ranging from mild to severe.
In this prospective, single-center, open-label, nonrandomized, and single-arm study patients received a baseline evaluation including retinal imaging, then 1 hour of negative pressure application through the BGS, followed by repeat retinal imaging. Participants then used the BGS at home for 1 month and underwent a repeat evaluation at the conclusion of the trial.
Changes in nerve fiber layer thickness, OCTA vascular parameters, and FPF scores.
Mean baseline IOP was 18.0±3.1 mmHg and there was no significant change in IOP at follow-up. At 1 month compared with baseline, there was a statistically significant improvement in FPF optic nerve head rim scores (12.7±11.6 to 10.5±7.5; P =0.04). In addition, there was a trend toward an increase in retinal nerve fiber layer thickness after 1 month (69.5±14.2 to 72.0±13.7; P =0.1), but there were no statistically significant differences observable with any of the OCTA vascular parameters either at 1 hour or after 1 month.
There were no significant changes observable using conventional OCT imaging after short-term use of the BGS, although metabolic imaging using FPF may be a useful potential biomarker to complement existing investigations. Additional studies are warranted to further investigate these changes.
在青光眼患者中短期使用平衡镜系统（BGS）与传统眼部相干断层扫描（OCT）成像观察到的变化无关，但使用周边脉络膜黄蛋白荧光（FPF）进行代谢成像可能代表一种有用的辅助研究。
确定 BGS 的降眼压效果是否伴有 OCT 测量的视网膜厚度变化、OCTA 测量的视网膜血管密度变化或使用眼底相机测量的新型周边代谢分析 FPF 变化。
前瞻性比较病例系列。
8 名开角型青光眼患者的 8 只眼，从轻度到重度不等。
在这项前瞻性、单中心、开放标签、非随机和单臂研究中，患者接受了基线评估，包括视网膜成像，然后通过 BGS 进行 1 小时的负压应用，然后重复视网膜成像。参与者随后在家中使用 BGS 1 个月，并在试验结束时进行重复评估。
神经纤维层厚度、OCTA 血管参数和 FPF 评分的变化。
平均基线眼压为 18.0±3.1mmHg，随访时眼压无显著变化。与基线相比，1 个月时 FPF 视神经头边缘评分有统计学意义的改善（12.7±11.6 至 10.5±7.5；P=0.04）。此外，1 个月后视网膜神经纤维层厚度有增加趋势（69.5±14.2 至 72.0±13.7；P=0.1），但在 1 小时或 1 个月后任何 OCTA 血管参数均无统计学意义。
在使用 BGS 短期治疗后，使用传统的 OCT 成像没有观察到明显的变化，尽管使用 FPF 进行代谢成像可能是一种有用的潜在生物标志物来补充现有的研究。需要进一步的研究来进一步探讨这些变化。
