Postgraduate Department of Botany, Ramananda College, Bishnupur, India.
Crit Rev Microbiol. 2023 Aug;49(4):499-514. doi: 10.1080/1040841X.2022.2082268. Epub 2022 Jun 13.
is a nontuberculous mycobacterium, associated with broncho-pulmonary infections in individuals suffering from cystic fibrosis, bronchiectasis, and pulmonary diseases. The risk factors for transmission include biofilms, contaminated water resources, fomites, and infected individuals. is extensively resistant to antibiotics. To date, there is no vaccine and combination antibiotic therapy is followed. However, drug toxicities, low cure rates, and high cost of treatment make it imperfect. Over the last 20 years, bioinformatic studies on have advanced our understanding of the pathogen. This review integrates knowledge from the analysis of genomes, microbiomes, genomic variations, phylogeny, proteome, transcriptome, secretome, antibiotic resistance, and vaccine design to further our understanding. The utility of genome-based studies in comprehending disease progression, surveillance, tracing transmission routes, and epidemiological outbreaks on a global scale has been highlighted. Furthermore, this review underlined the importance of using computational methodologies for pinpointing factors responsible for pathogen survival and resistance. We reiterate the significance of interdisciplinary research to fight In a nutshell, the outcome of computational studies can go a long way in creating novel therapeutic avenues to control mediated pulmonary infections.
是一种非结核分枝杆菌，与囊性纤维化、支气管扩张和肺部疾病患者的支气管肺部感染有关。传播的危险因素包括生物膜、受污染的水资源、污染物和感染个体。广泛对抗生素耐药。迄今为止，尚无疫苗，并且采用联合抗生素治疗。但是，药物毒性、治愈率低和治疗费用高昂使其并不完美。在过去的 20 年中，分枝杆菌的生物信息学研究增进了我们对病原体的了解。本综述整合了基因组、微生物组、基因组变异、系统发育、蛋白质组、转录组、分泌组、抗生素耐药性和疫苗设计分析的知识，以进一步加深理解。基于基因组的研究在理解疾病进展、监测、追踪传播途径和全球范围内的流行病学暴发方面的作用已得到强调。此外，本综述强调了使用计算方法确定导致病原体存活和耐药性的因素的重要性。我们重申跨学科研究对抗的重要性。简而言之，计算研究的结果可以为控制分枝杆菌引起的肺部感染开辟新的治疗途径。
