司他夫定和比较剂对临床少见非发酵革兰阴性杆菌的抗菌活性。
Antimicrobial activities of sitafloxacin and comparators against the clinical isolates of less common nonfermenting Gram-negative bacteria.
机构信息
Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China; Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, China.
Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China; Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, China.
出版信息
J Glob Antimicrob Resist. 2022 Sep;30:123-126. doi: 10.1016/j.jgar.2022.06.003. Epub 2022 Jun 10.
OBJECTIVES
To evaluate in vitro activities of sitafloxacin and comparators against the clinical isolates of less common nonfermenting Gram-negative bacteria (NFGNB).
METHODS
The isolates of less common NFGNB were collected during a long period spanning five years from 2016 to 2020 in Huashan Hospital, Fudan University in Shanghai. A broth microdilution method was used to determine the minimum inhibitory concentrations (MICs) of sitafloxacin and comparators.
RESULTS
In terms of MIC values, sitafloxacin was highly active against Stenotrophomonas maltophilia (0.25/1 mg/L), Burkholderia cepacia complex (0.25/2 mg/L), Achromobacter xylosoxidans (0.25/1 mg/L), and Chryseobacterium gleum (1/2 mg/L), but less active for Elizabethkingia (1/8 mg/L) and Chryseobacterium indologenes (16/32 mg/L). Sitafloxacin was more active than other fluoroquinolones against these NFGNB except Chryseobacterium.
CONCLUSION
The results are helpful for clinicians to be aware of the role of sitafloxacin in managing the infections caused by these NFGNB.
目的
评估司他沙星及对照药物对少见非发酵革兰阴性菌（NFGNB）临床分离株的体外活性。
方法
2016 年至 2020 年期间，从上海复旦大学华山医院采集了少见非发酵革兰阴性菌的分离株。采用肉汤微量稀释法测定司他沙星和对照药物的最小抑菌浓度（MIC）。
结果
司他沙星对嗜麦芽窄食单胞菌（0.25/1 mg/L）、洋葱伯克霍尔德菌复合体（0.25/2 mg/L）、木糖氧化无色杆菌（0.25/1 mg/L）和粘质沙雷菌（1/2 mg/L）具有高度活性，但对伊丽莎白菌（1/8 mg/L）和琼氏不动杆菌（16/32 mg/L）的活性较低。司他沙星对这些 NFGNB 的活性优于其他氟喹诺酮类药物，除了对黄杆菌属。
结论
这些结果有助于临床医生了解司他沙星在治疗这些 NFGNB 引起的感染中的作用。
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