Department of Urology, The First Hospital of Jilin University, Changchun 130001, China.
Cancer Center, Department of Hematology, The First Hospital of Jilin University, Changchun 130001, China.
Crit Rev Oncol Hematol. 2022 Aug;176:103732. doi: 10.1016/j.critrevonc.2022.103732. Epub 2022 Jun 11.
Prostate cancer (PCa) is a highly prevalent disease that affects men's health worldwide and is the second most common malignancy in males. Ferroptosis is a novel form of programmed cell death characterized by iron overload and the accumulation of lipid peroxidation, which differs from the regulated cell death modes of necrosis, apoptosis, and autophagy. Substantial progress has been achieved in researching the occurrence and regulatory mechanisms of ferroptosis, which is closely associated with cancer initiation, progression, and suppression and is expected to become a new breakthrough point in the PCa treatment. This review will summarize the mechanisms involved in PCa, and we detail the molecular mechanisms of ferroptosis and its role in PCa treatment.
前列腺癌（PCa）是一种在全球范围内影响男性健康的高发疾病，也是男性中第二常见的恶性肿瘤。铁死亡是一种新型的程序性细胞死亡形式，其特征是铁过载和脂质过氧化的积累，与坏死、细胞凋亡和自噬等调节性细胞死亡模式不同。铁死亡的发生和调控机制的研究取得了重大进展，它与癌症的发生、发展和抑制密切相关，有望成为 PCa 治疗的新突破点。本文综述了 PCa 发生发展的相关机制，并详细阐述了铁死亡的分子机制及其在 PCa 治疗中的作用。
