Department of Psychiatry and Behavioral Health, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
Department of Psychiatry and Behavioral Health, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
Child Adolesc Psychiatr Clin N Am. 2022 Jul;31(3):479-498. doi: 10.1016/j.chc.2022.02.003. Epub 2022 May 11.
Emotional dysregulation (ED) manifesting as irritability or aggression produces appreciable impairment in children with attention deficit hyperactivity disorder and a main reason why they present for treatment. Central nervous system (CNS) stimulants seem to be a safe and tolerable treatment of most youth with these presentations. Optimization of CNS stimulants dose in combination with psychosocial interventions led to reductions in ED. Randomized controlled trials support that addition of risperidone further reduces aggression when these treatments are not sufficient. There is evidence for the efficacy of divalproex, molindone and selective serotonin reuptake inhibitor improve these outcomes when used as adjunct to CNS stimulants.
情绪失调（ED）表现为易怒或攻击性，会对患有注意缺陷多动障碍的儿童造成明显的损害，也是他们寻求治疗的主要原因。中枢神经系统（CNS）兴奋剂似乎是治疗大多数此类患者的安全且可耐受的方法。CNS 兴奋剂剂量的优化与心理社会干预相结合可减少 ED。随机对照试验支持，当这些治疗方法不足时，加用利培酮可进一步减少攻击性。有证据表明，丙戊酸钠、莫林酮和选择性 5-羟色胺再摄取抑制剂作为 CNS 兴奋剂的辅助治疗可改善这些结果。
