Afshari Elham, Dehghan Farzaneh, Vakili Mohammad Ali, Abbasi Marzieh
Department of community Oral Health, School of Dentistry, Golestan University of Medical Science, Golestan, Gorgan, Iran.
Department of Pediatric Dentistry, School of Dentistry, Golestan University of Medical Science, Golestan, Gorgan, Iran.
BDJ Open. 2022 Jun 13;8(1):15. doi: 10.1038/s41405-022-00111-x.
Molar-incisor hypomineralization is a developmental defect of enamel with clinical features vary from demarcated opacities to severe tissue breakdown which calls for considerable preventive and interceptive measures. The aim of this article was to systematically review the literature on the prevalence of MIH in Iran and highlight the condition in Iranian children.
A systematic search of literature was conducted in Scopus, Pubmed, Ovid, Embase, Web of Science, and Google-Scholar as well as national Iranian database and digital archives of dental schools from the beginning of 2000 to the end of 2021 for published and unpublished studies. Data from cross-sectional, cohort, and case-control studies on prevalence of molar-incisor hypomineralization among 6-13-year-old children was gathered, using the following MeSH terms and keywords and their Persian equivalents: Prevalence, Hypomineralisation, Hypomineralization, MIH, "molar incisor", "molar-incisor", "cheese molars", "Hypomineralised first permanent molars", "Hypomineralized first permanent molars", "developmental defects of enamel", "enamel developmental defects", Iran*. Methodological quality and the risk of bias of quantitative studies was assessed using a modified version of Newcastle-Ottawa Scale. Due to the considerable clinical and statistical heterogeneity of the included studies, pooling of data through meta-analysis was not possible. Therefore, a descriptive synthesis of data was performed.
Fifteen cross-sectional studies with a total number of 12011 participants were included in the systematic review. The prevalence of MIH ranged from 5.1% to 25.6%. All of the included studies were at a moderate risk of bias (NOS of 4-6). The lowest prevalence of MIH was reported in Kerman (5.14%) and the highest in Tehran (25.6%). Substantial methodological, clinical and statistical heterogeneity was observed.
This is the first study to systematically review the available literature on MIH prevalence in Iran. However, the present review has some limitations such as limited number of included studies, large heterogeneity of the research, and moderate quality of included studies. Further high-quality research is warranted.
磨牙-切牙矿化不全是一种牙釉质发育缺陷，其临床特征从界限分明的釉质混浊到严重的组织破坏不等，这需要采取大量的预防和阻断措施。本文旨在系统回顾伊朗磨牙-切牙矿化不全患病率的相关文献，并突出伊朗儿童的患病情况。
在Scopus、Pubmed、Ovid、Embase、Web of Science和Google Scholar以及伊朗国家数据库和牙科学院的数字档案中，对2000年初至2021年底发表和未发表的研究进行了文献系统检索。收集了关于6-13岁儿童磨牙-切牙矿化不全患病率的横断面研究、队列研究和病例对照研究的数据，使用以下医学主题词（MeSH）及其波斯语对应词：患病率、矿化不足、磨牙-切牙矿化不全、“磨牙切牙”、“磨牙-切牙”、“奶酪磨牙”、“矿化不足的第一恒磨牙”、“矿化不全的第一恒磨牙”、“牙釉质发育缺陷”、“牙釉质发育异常”、伊朗*。采用纽卡斯尔-渥太华量表的修改版评估定量研究的方法学质量和偏倚风险。由于纳入研究存在相当大的临床和统计异质性，无法通过荟萃分析合并数据。因此，对数据进行了描述性综合分析。
系统评价纳入了15项横断面研究，共有12011名参与者。磨牙-切牙矿化不全的患病率在5.1%至25.6%之间。所有纳入研究的偏倚风险均为中度（纽卡斯尔-渥太华量表评分为4-6）。克尔曼报告的磨牙-切牙矿化不全患病率最低（5.14%），德黑兰最高（25.6%）。观察到显著的方法学、临床和统计异质性。
这是第一项系统回顾伊朗磨牙-切牙矿化不全患病率现有文献的研究。然而，本综述存在一些局限性，如纳入研究数量有限、研究异质性大以及纳入研究质量中等。需要进一步开展高质量研究。
