Awwad Abdelrahman, Hamad Rakan, Schiffner Ulrich, Splieth Christian H, Schmoeckel Julian
Department of Preventive and Pediatric Dentistry, University of Greifswald, Greifswald, Germany Email:
Center for Dental and Oral Medicine, Department of Periodontics, Preventive and Restorative Dentistry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Acta Stomatol Croat. 2023 Dec;57(4):381-394. doi: 10.15644/asc57/4/8.
The aim of this systematic review and meta-analysis is to assess the association between the MIH presence as well as the severity and OHRQoL in children.
Relevant studies were identified in PubMed, Embase, Cochrane and Google Scholar. Studies involving MIH and OHRQoL in children were included. A methodological quality assessment of included studies was performed using the Newcastle-Ottawa Scale (NOS) and its adapted version for cross-sectional studies. Random effects models were used to estimate summary effect measures for the association between MIH presence (presence vs. absence) as well as severity (moderate/severe MIH vs. no MIH) and OHRQoL using generic inverse variance meta-analyses. Tests for heterogeneity, publication bias and sensitivity of results were also performed.
Out of 1696 identified publications 11 studies reporting on 5,017 children were included in the meta-analysis assessing the impact of MIH presence. There was no statistically significant association between the presence of MIH and lower OHRQoL in affected children (OR = 1.72, 95% CI = 0.99-2.98). Concerning MIH severity and its impact on OHRQoL, a sum of 6 studies were included in the meta-analysis involving a total of 2,595 children. There was a significant association between moderate/severe MIH and lower OHRQoL in affected children (OR = 3.43, 95% CI = 1.69-6.98).
Moderate/Severe MIH has a significant and clinically relevant negative impact on OHRQoL, and it should therefore be addressed adequately. Future research should also consider the impact of a uniform MIH diagnosis and precise severity criteria.
本系统评价和荟萃分析旨在评估儿童中MIH的存在、严重程度与口腔健康相关生活质量（OHRQoL）之间的关联。
在PubMed、Embase、Cochrane和谷歌学术中检索相关研究。纳入涉及儿童MIH和OHRQoL的研究。使用纽卡斯尔-渥太华量表（NOS）及其适用于横断面研究的版本对纳入研究进行方法学质量评估。采用随机效应模型，通过通用逆方差荟萃分析估计MIH存在（存在与不存在）以及严重程度（中度/重度MIH与无MIH）与OHRQoL之间关联的汇总效应量。还进行了异质性检验、发表偏倚检验和结果敏感性检验。
在1696篇已识别的出版物中，有11项报告了5017名儿童的研究被纳入评估MIH存在影响的荟萃分析。在受影响儿童中，MIH的存在与较低的OHRQoL之间无统计学显著关联（OR = 1.72，95%CI = 0.99 - 2.98）。关于MIH严重程度及其对OHRQoL的影响，荟萃分析纳入了6项研究，共涉及2595名儿童。在受影响儿童中，中度/重度MIH与较低的OHRQoL之间存在显著关联（OR = 3.43，95%CI = 1.69 - 6.98）。
中度/重度MIH对OHRQoL具有显著且临床相关的负面影响，因此应予以充分关注。未来研究还应考虑统一MIH诊断和精确严重程度标准的影响。
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