Department of Biomedical Engineering, Indiana University-Purdue University Indianapolis, SL 220B, 723 W. Michigan St., Indianapolis, IN, 46202, USA.
Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, IN, USA.
Sci Rep. 2022 Jun 13;12(1):9804. doi: 10.1038/s41598-022-14068-2.
Bone is a hierarchical material formed by an organic extracellular matrix and mineral where each component and their physical relationship with each other contribute to fracture resistance. Bone quality can be affected by nutrition, and dietary supplements that are marketed to improve overall health may improve the fracture resistance of bone. To test this, 11 week old female C57BL/6 mice were fed either collagen, chondroitin sulfate, glucosamine sulfate, or fish oil 5 times a week for 8 weeks. Femurs, tibiae, and vertebrae were scanned with micro-computed tomography and then mechanically tested. Glucosamine and fish oil lowered elastic modulus, but did not alter the overall strength of the femur. There were no differences in bone mechanics of the tibiae or vertebrae. Overall, the data suggest that dietary supplements did little to improve bone quality in young, healthy mice. These supplements may be more effective in diseased or aged mice.
骨是一种由有机细胞外基质和矿物质组成的分级材料，其中每个成分及其与其他成分的物理关系都有助于提高抗骨折能力。骨质量可能受到营养的影响，而市场上销售的旨在改善整体健康的膳食补充剂可能会提高骨的抗骨折能力。为了验证这一点，将 11 周龄的雌性 C57BL/6 小鼠每周喂食 5 次胶原蛋白、硫酸软骨素、硫酸葡萄糖胺或鱼油，持续 8 周。使用微计算机断层扫描对股骨、胫骨和椎骨进行扫描，然后进行机械测试。葡萄糖胺和鱼油降低了弹性模量，但没有改变股骨的整体强度。胫骨或椎骨的骨力学没有差异。总的来说，数据表明膳食补充剂对年轻健康小鼠的骨质量几乎没有改善作用。这些补充剂在患病或年老的小鼠中可能更有效。
