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无机多聚磷酸盐在线粒体能量代谢和病理学中的作用。

Inorganic Polyphosphate in Mitochondrial Energy Metabolism and Pathology.

机构信息

Department of Molecular Pathobiology, New York University, New York, NY, USA.

出版信息

Prog Mol Subcell Biol. 2022;61:15-26. doi: 10.1007/978-3-031-01237-2_2.

DOI:10.1007/978-3-031-01237-2_2
PMID:35697935
Abstract

In this chapter, the current understanding of the potential roles played by polyphosphate in mitochondrial function with a specific focus on energy metabolism and mitochondrial pathologies caused by stress is summarized. Here we will discuss details of the possible ion transporting mechanisms of mitochondria that might involve polyP and their role in mitochondrial physiology and pathology are discussed.

摘要

在本章中，总结了目前对多聚磷酸盐在线粒体功能中可能发挥的作用的理解，特别关注能量代谢和应激引起的线粒体病变。在这里，我们将讨论可能涉及多聚磷酸盐的线粒体的可能离子转运机制的细节，并讨论它们在线粒体生理学和病理学中的作用。

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Inorganic Polyphosphate in Mitochondrial Energy Metabolism and Pathology.无机多聚磷酸盐在线粒体能量代谢和病理学中的作用。
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2
Depletion of mitochondrial inorganic polyphosphate (polyP) in mammalian cells causes metabolic shift from oxidative phosphorylation to glycolysis.哺乳动物细胞中线粒体无机多聚磷酸盐（polyP）的耗竭会导致代谢从氧化磷酸化转向糖酵解。
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Cellular calcification induced by inorganic polyphosphate involves ATP depletion and opening of the mitochondrial permeability transition pore (mPTP).无机多聚磷酸盐诱导的细胞钙化涉及三磷酸腺苷（ATP）耗竭和线粒体通透性转换孔（mPTP）的开放。
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本文引用的文献

1
C subunit of the ATP synthase is an amyloidogenic calcium dependent channel-forming peptide with possible implications in mitochondrial permeability transition.ATP 合酶 C 亚基是一种淀粉样原纤维钙依赖性通道形成肽，可能与线粒体通透性转换有关。
Sci Rep. 2021 Apr 22;11(1):8744. doi: 10.1038/s41598-021-88157-z.
2
Depletion of mitochondrial inorganic polyphosphate (polyP) in mammalian cells causes metabolic shift from oxidative phosphorylation to glycolysis.哺乳动物细胞中线粒体无机多聚磷酸盐（polyP）的耗竭会导致代谢从氧化磷酸化转向糖酵解。
Biochem J. 2021 Apr 30;478(8):1631-1646. doi: 10.1042/BCJ20200975.
3
Electrophysiological properties of the mitochondrial permeability transition pores: Channel diversity and disease implication.
线粒体通透性转换孔的电生理学特性：通道多样性及疾病意义。
Biochim Biophys Acta Bioenerg. 2021 Mar 1;1862(3):148357. doi: 10.1016/j.bbabio.2020.148357. Epub 2020 Dec 24.
4
Amyloid β, α-synuclein and the c subunit of the ATP synthase: Can these peptides reveal an amyloidogenic pathway of the permeability transition pore?淀粉样β蛋白、α-突触核蛋白和 ATP 合酶的 c 亚基：这些肽能否揭示通透性转换孔的淀粉样形成途径？
Biochim Biophys Acta Biomembr. 2021 Mar 1;1863(3):183531. doi: 10.1016/j.bbamem.2020.183531. Epub 2020 Dec 10.
5
Inorganic polyphosphate is produced and hydrolyzed in F0F1-ATP synthase of mammalian mitochondria.无机多聚磷酸盐在哺乳动物线粒体的F0F1-ATP合酶中产生并水解。
Biochem J. 2020 Apr 30;477(8):1515-1524. doi: 10.1042/BCJ20200042.
6
Inorganic polyphosphate is required for sustained free mitochondrial calcium elevation, following calcium uptake.无机多聚磷酸盐是钙摄取后持续升高游离线粒体钙所必需的。
Cell Calcium. 2020 Mar;86:102127. doi: 10.1016/j.ceca.2019.102127. Epub 2019 Dec 9.
7
Inorganic Polyphosphates As Storage for and Generator of Metabolic Energy in the Extracellular Matrix.无机多聚磷酸盐作为细胞外基质中代谢能量的储存和产生物质。
Chem Rev. 2019 Dec 26;119(24):12337-12374. doi: 10.1021/acs.chemrev.9b00460. Epub 2019 Nov 18.
8
Polyphosphate as a donor of high-energy phosphate for the synthesis of ADP and ATP.多聚磷酸盐作为用于合成二磷酸腺苷（ADP）和三磷酸腺苷（ATP）的高能磷酸供体。
J Cell Sci. 2017 Aug 15;130(16):2747-2756. doi: 10.1242/jcs.204941. Epub 2017 Jul 7.
9
Mitochondrial permeability transition pore induction is linked to formation of the complex of ATPase C-subunit, polyhydroxybutyrate and inorganic polyphosphate.线粒体通透性转换孔的诱导与ATP酶C亚基、聚羟基丁酸酯和无机多磷酸盐复合物的形成有关。
Cell Death Discov. 2016 Dec 5;2:16070. doi: 10.1038/cddiscovery.2016.70. eCollection 2016.
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Trends Biochem Sci. 2017 Mar;42(3):219-231. doi: 10.1016/j.tibs.2016.10.008. Epub 2016 Nov 19.