Fertility Medical Group, São Paulo, Brazil.
Sapientiae Institute - Centro de Estudos e Pesquisa em Reprodução Humana Assistida, São Paulo, Brazil.
Andrologia. 2022 Sep;54(8):e14485. doi: 10.1111/and.14485. Epub 2022 Jun 13.
The objective of this cross-sectional study was to investigate the impact of paternal age on the outcomes of intracytoplasmic sperm injection (ICSI) cycles at different values of maternal age. A total of 21,960 injected oocytes deriving from 3837 ICSI cycles performed between January 2014 and October 2020, performed in a private university-affiliated in vitro fertilization centre was included. The main effects of maternal and paternal age, as well as the effect of their product (interaction term) on embryo development and pregnancy outcomes were investigated considering the clustering of data. The coefficients for the interaction term were statistically significant for blastocyst development, top-quality blastocyst, implantation, pregnancy, miscarriage, and live-birth rates. For every 1-year increase in paternal age, the odds ratio of live-birth reduces by 1% in females aged 37 years, 1.6% in those aged 38 years, 2.4% in 39-year-old females, 5% in 42-year-old females and so on. An increase in the interaction term by 1 year decreases the pregnancy rate by 0.4% and live-birth rate by 0.8 and increases the miscarriage rate by 1.2%. The slopes of maternal age on blastulation, blastocyst quality, and implantation, pregnancy, miscarriage, and live-birth rate significantly changed (worsened) for every year increase in paternal age.
本横断面研究旨在探讨在不同母体年龄值下，父体年龄对卵胞浆内单精子注射（ICSI）周期结局的影响。共纳入 21960 枚注射卵母细胞，这些卵母细胞源自 2014 年 1 月至 2020 年 10 月期间在一家私立大学附属体外受精中心进行的 3837 个 ICSI 周期。考虑到数据的聚类，研究了母体年龄和父体年龄的主要影响以及它们的乘积（交互项）对胚胎发育和妊娠结局的影响。对于囊胚发育、优质囊胚、着床、妊娠、流产和活产率，交互项的系数具有统计学意义。对于 37 岁的女性，每增加 1 岁，活产率的优势比降低 1%；对于 38 岁的女性，降低 1.6%；对于 39 岁的女性，降低 2.4%；对于 42 岁的女性，降低 5%，以此类推。交互项增加 1 年，妊娠率降低 0.4%，活产率降低 0.8%，流产率增加 1.2%。随着父体年龄的增加，母体年龄对卵裂、囊胚质量和着床、妊娠、流产和活产率的斜率显著改变（恶化）。
