Institute of Nutrition and Health, School of Public Health, Qingdao University, Qingdao, Shandong, China.
Institute of Nutrition and Health, School of Public Health, Qingdao University, Qingdao, Shandong, China.
Carbohydr Polym. 2022 Sep 1;291:119359. doi: 10.1016/j.carbpol.2022.119359. Epub 2022 Mar 15.
Previous studies showed that sodium alginates of different molecular weights reduced postprandial glucose differently. We hypothesize that the differential modulation of hyperglycemia by sodium alginates with different molecular weights may be associated with their differential regulations of serum metabolites and gut microbiota. In this work, high-fat diet-fed mice were supplemented with high- and low-molecular-weight sodium alginate (H-SA, 3350 kDa; L-SA, 131 kDa). Blood glucose/lipid parameters, serum metabolites and gut microbiota were measured. Compared with L-SA, H-SA more significantly reduced fasting blood glucose, HOMA-IR, total cholesterol and body fat; H-SA more significantly enriched serum metabolites, including certain lipids, branched-chain amino acids, and vitamin D and E derivatives. These changes were correlated with the differential modulation of gut microbiota by H-SA and L-SA. In conclusion, the differential effects of sodium alginates with different molecular weights in alleviating hyperglycemia were associated with their differential modulations of serum metabolites and gut microbiota.
先前的研究表明，不同分子量的海藻酸钠对餐后血糖的降低作用不同。我们假设，不同分子量的海藻酸钠对高血糖的差异化调节可能与其对血清代谢物和肠道微生物群的差异化调节有关。在这项工作中，高脂饮食喂养的小鼠补充了高分子量和低分子量的海藻酸钠（H-SA，3350 kDa；L-SA，131 kDa）。测量了血糖/血脂参数、血清代谢物和肠道微生物群。与 L-SA 相比，H-SA 更显著地降低了空腹血糖、HOMA-IR、总胆固醇和体脂肪；H-SA 更显著地富集了血清代谢物，包括某些脂质、支链氨基酸以及维生素 D 和 E 的衍生物。这些变化与 H-SA 和 L-SA 对肠道微生物群的差异化调节有关。总之，不同分子量的海藻酸钠在缓解高血糖方面的差异作用与它们对血清代谢物和肠道微生物群的差异化调节有关。
