兴奋剂和致幻剂对大鼠穿梭回避行为影响的比较

Comparison of stimulants and hallucinogens on shuttle avoidance in rats.

作者信息

Davis W M, Hatoum H T

出版信息

Gen Pharmacol. 1987;18(2):123-8. doi: 10.1016/0306-3623(87)90237-0.

Abstract

Rats were trained to a high level of performance of a conditioned avoidance response in a shuttlebox to test effects of several classical stimulants in comparison to a variety of hallucinogens. A previously-reported biphasic pattern of effects of mescaline on shuttle avoidance was replicated and extended to 12 other hallucinogens of both phenylethylamine and indolealkylamine classes. Response patterns of hallucinogens could be differentiated from 3 stimulants and from a methoxyamphetamine compound that lacks hallucinogenic activity.

摘要

训练大鼠在穿梭箱中高水平地执行条件性回避反应，以测试几种经典兴奋剂与多种致幻剂相比的效果。之前报道的三甲氧苯乙胺对穿梭回避的双相效应模式得到了重复，并扩展到苯乙胺和吲哚烷基胺类的其他12种致幻剂。致幻剂的反应模式可以与3种兴奋剂以及一种缺乏致幻活性的甲氧基苯丙胺化合物区分开来。