Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, Wuxi 214122, Jiangsu Province, People's Republic of China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, People's Republic of China; Collaborative Innovation Center for Food Safety and Quality Control, Jiangnan University, Wuxi, 214122, Jiangsu Province, People's Republic of China.
Insistute of Agro-products Processing Science and Technology, Academy of Agricultural Science, Nanning 530007, Guangxi Province, People's Republic of China.
Carbohydr Polym. 2022 Sep 1;291:119628. doi: 10.1016/j.carbpol.2022.119628. Epub 2022 May 18.
Paclitaxel, a clinical chemotherapy drug commonly used in the past few years, is greatly limited by its low therapeutic index. Starch and its derivatives have gained wide interest from researchers owing to their unique hydrophilic and hydrophobic properties resulting from their various modifications, which exert the effect-enhancing and toxicity-reducing activity to paclitaxel in vivo and in vitro. This review summarizes the research progress toward different kinds of starch-based carriers, whether oral or injectable. In addition, we discuss the complex properties of starch derivatives toward physically complexed or chemically conjugated paclitaxel. The corresponding complex configurations are suggested. Starch-based carriers can act as permeability enhancers because they may interact with the unstirred water layer that separates hydrophobic drugs from biological membranes, even altering the barrier properties of the membrane. The information presented in this review may be used as a reference for future hydrophobic drug carrier studies.
紫杉醇是一种过去几年中常用的临床化疗药物，但由于其治疗指数低，应用受到很大限制。淀粉及其衍生物由于其各种修饰而具有独特的亲水性和疏水性，在体内和体外对紫杉醇表现出增效减毒作用，因此受到研究人员的广泛关注。本文综述了不同种类的淀粉基载体（口服或注射）的研究进展。此外，我们还讨论了淀粉衍生物对物理复合物或化学结合紫杉醇的复杂性质。提出了相应的复合结构。淀粉载体可以作为渗透增强剂，因为它们可能与将疏水性药物与生物膜隔开的未搅动水层相互作用，甚至改变膜的屏障性质。本文提供的信息可作为未来疏水药物载体研究的参考。
