Universitat Internacional de Catalunya, Sant Cugat del Vallès, España.
Fundació Institut Universitari per la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Barcelona, España.
Rev Neurol. 2022 Jun 16;74(12):392-402. doi: 10.33588/rn.7412.2022019.
Huntington's disease (HD) is a degeneration of the brain.
To assess the evidence of the physical activity (PA) to improve motor function, gait speed, and walking endurance in individuals with HD.
Two reviewers independently screened references and selected relevant studies to identify randomized controlled trials (RCT), from MEDLINE/PubMed, CENTRAL, PEDro, Scopus, CINAHL, Web of Science databases from inception to September 2021. Two reviewers evaluated risk of bias by the PEDro scale. The primary outcome was assessed motor function, gait speed and walking endurance as a secondary outcome was evaluated activities of daily living (ADL), lower limb functionality strenght, balance, mobility and cognition function in HD.
Eight RCT were finally included (231 individuals). Forest plots showed a positive effect for gait endurance, the mean difference (MD) was 17.40 (95% CI from 5.40 to 29.35; p = 0.004), the MD lower limb functionality strength was 1.76 (95% CI from 0.18 to 3.33; p = 0.03) favoring PA group and the MD cognition function was 1.83 (95% CI from 0.50 to 3.16; p = 0.007). No benefits were found for motor function, gait speed, ADL, balance and mobility.
Positive effects of programs PA were observed for walking endurance lower limb functionality strenght and cognition function in low and moderate stage of HD. However, no benefits were found for motor function, gait speed, ADL, balance and mobility. All authors included aerobic exercises in their programs but is unclear if vigorous and intensive PA is optimal for individuals with HD.
亨廷顿病（HD）是一种大脑退化。
评估身体活动（PA）改善 HD 患者运动功能、步态速度和步行耐力的证据。
两位审查员独立筛选参考文献并选择相关研究，以确定从 MEDLINE/PubMed、CENTRAL、PEDro、Scopus、CINAHL、Web of Science 数据库中从成立到 2021 年 9 月的随机对照试验（RCT）。两位审查员使用 PEDro 量表评估偏倚风险。主要结局是评估运动功能、步态速度和步行耐力，次要结局是评估日常生活活动（ADL）、下肢功能强度、平衡、移动性和认知功能。
最终纳入 8 项 RCT（231 人）。森林图显示，在步态耐力方面，PA 组的效果为正，平均差异（MD）为 17.40（95%置信区间从 5.40 到 29.35；p = 0.004），下肢功能强度 MD 为 1.76（95%置信区间从 0.18 到 3.33；p = 0.03），认知功能 MD 为 1.83（95%置信区间从 0.50 到 3.16；p = 0.007）。在运动功能、步态速度、ADL、平衡和移动性方面没有发现益处。
在 HD 的低、中阶段，PA 方案对步行耐力、下肢功能强度和认知功能具有积极影响。然而，在运动功能、步态速度、ADL、平衡和移动性方面没有发现益处。所有作者在他们的方案中都包括了有氧运动，但不清楚剧烈和高强度的 PA 是否对 HD 患者是最佳的。
