Mallick Bipadabhanjan, Malik Sarthak
Gastroenterology, Kalinga Institute of Medical Sciences (KIMS), Bhubaneswar, IND.
Gastroenterology, Fortis Escorts Heart Institute, New Delhi, IND.
Cureus. 2022 May 10;14(5):e24874. doi: 10.7759/cureus.24874. eCollection 2022 May.
Ulcerative colitis (UC) is a relapsing and remitting chronic inflammatory disease of the large intestine characterized by bloody diarrhea, abdominal pain, urgency, and tenesmus. Rapid induction and maintenance of remission are the primary goals of treatment. Azathioprine (AZA), a purine analog, has been utilized as an immuno-modulator to maintain remission in UC. AZA has been used for a long time, but there is still controversy about its effectiveness, drug interactions, and side effects in people with UC. We conducted a comprehensive analysis of the literature and present a detailed insight into the role of AZA in patients with UC.
溃疡性结肠炎（UC）是一种大肠的复发性和缓解性慢性炎症性疾病，其特征为血性腹泻、腹痛、便急和里急后重。快速诱导和维持缓解是治疗的主要目标。硫唑嘌呤（AZA）作为一种嘌呤类似物，已被用作免疫调节剂以维持UC的缓解。AZA已使用很长时间，但关于其在UC患者中的有效性、药物相互作用和副作用仍存在争议。我们对文献进行了全面分析，并对AZA在UC患者中的作用进行了详细阐述。
