Ott J, Lathrop G M
Genet Epidemiol. 1987;4(1):51-7. doi: 10.1002/gepi.1370040107.
For the case of three-point linkage analysis, a simple goodness-of-fit test is proposed to test the order of gene loci. To use it for testing one locus order against another, one may apply the principle that evidence for one order comes from lack of fit of the observations to the other order. With n = 30 offspring from a phase known triple backcross mating, at a recombination fraction of 20% between adjacent loci, the test achieves a power of 80% (5% significance level). Interference (real interference as well as interference assumed in the analysis) increases power.
对于三点连锁分析的情况，提出了一种简单的拟合优度检验来检验基因座的顺序。为了用它来检验一种基因座顺序与另一种顺序，人们可以应用这样的原则：一种顺序的证据来自于观测值与另一种顺序的不拟合。对于来自已知相的三重回交交配的30个后代，在相邻基因座之间的重组率为20%时，该检验在5%的显著性水平下达到80%的检验功效。干扰（实际干扰以及分析中假设的干扰）会提高检验功效。
