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韩国 COVID-19 控制的最佳社交距离政策:基于模型的分析。

Optimal Social Distancing Policy for COVID-19 Control in Korea: A Model-Based Analysis.

机构信息

Section of Infectious Disease, Department of Medicine, Boston Medical Center, Boston, MA, USA.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

出版信息

J Korean Med Sci. 2022 Jun 13;37(23):e189. doi: 10.3346/jkms.2022.37.e189.

Abstract

BACKGROUND

Since March 2020, when coronavirus disease 2019 (COVID-19) was declared a pandemic, many countries have applied unprecedented restrictive measures to contain the spread of the virus. This study aimed to explore the optimal social distancing policy for COVID-19 control in South Korea to safely reopen the society.

METHODS

We developed an age-specific, deterministic compartment epidemic model to examine the COVID-19 control decision-making process, including the epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) between 1 July 2021 and 30 December 2022. The model consists of the natural history of COVID-19, testing performance, vaccinations, and social distancing enforcement measures to detect and control SARS-CoV-2. We modelled potential intervention scenarios with three distinct components: 1) social distancing duration and level; 2) testing intensity; and 3) vaccination uptake rate. The primary and secondary outcomes were COVID-19 incidence and prevalence of severe patients requiring intensive care unit (ICU) care.

RESULTS

Four (or more) months of social distancing (that can reduce 40-60% transmission) may mitigate epidemic resurgence and ICU demand in the future and keep the cases below the capacity limit if the testing intensity and vaccination rate remain constant or increase by 20% (with respect to the current level). In contrast, two months of strict social distancing enforcement may also successfully mitigate future epidemic surge and ICU demand as long as testing intensity and vaccination rates are increased by 20%.

CONCLUSION

In South Korea, given the relatively high vaccination coverage and low incidence, four or more months of social distancing enforcement can effectively mitigate epidemic resurgence after lifting the social distancing measures. In addition, increasing the testing intensity and vaccination rate may help reduce necessary social distancing levels and duration to prevent a future epidemic resurgence and mitigate social and economic damage.

摘要

背景

自 2020 年 3 月宣布 COVID-19 大流行以来,许多国家已采取前所未有的限制措施来遏制病毒传播。本研究旨在探讨韩国 COVID-19 控制的最佳社会隔离政策,以安全重启社会。

方法

我们开发了一种特定年龄的确定性隔间传染病模型,以研究 COVID-19 控制决策过程,包括 2021 年 7 月 1 日至 2022 年 12 月 30 日之间严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 的流行病学。该模型由 COVID-19 的自然史、检测性能、疫苗接种和社会隔离执行措施组成,用于检测和控制 SARS-CoV-2。我们对三种不同成分的潜在干预情景进行建模:1)社会隔离持续时间和水平;2)检测强度;3)疫苗接种率。主要和次要结局是 COVID-19 发病率和需要 ICU 护理的重症患者患病率。

结果

四个月(或更长时间)的社会隔离(可减少 40-60%的传播)可能减轻未来的疫情反弹和 ICU 需求,并在检测强度和疫苗接种率保持不变或增加 20%(相对于当前水平)的情况下将病例保持在容量限制以下。相反,如果检测强度和疫苗接种率增加 20%,两个月的严格社会隔离执行也可能成功减轻未来的疫情反弹和 ICU 需求。

结论

在韩国,鉴于相对较高的疫苗接种率和较低的发病率,实施四个月或更长时间的社会隔离措施可以有效减轻解除社会隔离措施后的疫情反弹。此外,增加检测强度和疫苗接种率可能有助于降低必要的社会隔离水平和持续时间,以防止未来的疫情反弹并减轻社会和经济损失。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b07e/9194485/8950f35367d0/jkms-37-e189-g001.jpg

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