抗酿酒酵母抗体与类风湿关节炎。

Anti-Saccharomyces cerevisiae Antibodies in Rheumatoid Arthritis.

机构信息

Laboratory of Immunology, Farhat Hached Hospital, Sousse, Tunisia.

Department of Immunology, Faculty of Pharmacy, Monastir University, Monastir, Tunisia.

出版信息

Lab Med. 2022 Nov 3;53(6):585-589. doi: 10.1093/labmed/lmac054.

DOI:10.1093/labmed/lmac054

PMID:35699491

Abstract

OBJECTIVE

This study was conducted to evaluate the frequency of anti-Saccharomyces cerevisiae antibodies (ASCA) in patients with rheumatoid arthritis (RA).

METHODS

Eighty-three RA patients with positive anti-cyclic citrullinated antibodies (anti-CCP) and 160 healthy blood donors were included in this study. ASCA IgG and IgA were assessed with enzyme-linked immunosorbent assay.

RESULTS

The frequency of ASCA was significantly higher in RA patients than in healthy subjects (22.9% vs 3.7%, P < 10-3). Both ASCA IgG and ASCA IgA were significantly more frequent in RA patients than in the control group (20.5% vs 3.1%, P < 10-3and 9.6% vs 0.6%, P = .002, respectively). ASCA IgG and ASCA IgA levels were significantly higher in RA patients than in healthy subjects (7.8 ± 8.4 U/mL vs 2.3 ± 2.8 U/mL, P < 10-6 and 6.2 ± 10.9 U/mL vs 3.4 ± 1.7 U/mL, P = .002, respectively).

CONCLUSION

A high frequency of ASCA IgG and ASCA IgA has been found in RA patients.

摘要

目的

本研究旨在评估抗酿酒酵母抗体（ASCA）在类风湿关节炎（RA）患者中的频率。

方法

本研究纳入了 83 例抗环瓜氨酸肽抗体（抗-CCP）阳性的 RA 患者和 160 名健康献血者。采用酶联免疫吸附试验检测 ASCA IgG 和 IgA。

结果

RA 患者中 ASCA 的频率明显高于健康对照组（22.9% vs 3.7%，P<10-3）。RA 患者中 ASCA IgG 和 ASCA IgA 的频率均明显高于对照组（20.5% vs 3.1%，P<10-3；9.6% vs 0.6%，P=0.002）。RA 患者的 ASCA IgG 和 ASCA IgA 水平明显高于健康对照组（7.8±8.4 U/mL vs 2.3±2.8 U/mL，P<10-6；6.2±10.9 U/mL vs 3.4±1.7 U/mL，P=0.002）。