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Simultaneous injection of F-BF3- Cy3-ACUPA and non-radioactive Cy7-ACUPA probes: a promising pre-biopsy PET and ex vivo fluorescence imaging approach to evaluate prostate cancer.
Eur J Nucl Med Mol Imaging. 2021 Oct;48(11):3732-3733. doi: 10.1007/s00259-021-05344-w. Epub 2021 Apr 16.
2
PET Imaging Quantifying Ga-PSMA-11 Uptake in Metastatic Colorectal Cancer.正电子发射断层扫描（PET）成像定量检测转移性结直肠癌中 Ga-PSMA-11 的摄取。
J Nucl Med. 2020 Nov;61(11):1576-1579. doi: 10.2967/jnumed.119.233312. Epub 2020 May 1.
3
Imaging of Nonprostate Cancers Using PSMA-Targeted Radiotracers: Rationale, Current State of the Field, and a Call to Arms.使用 PSMA 靶向放射性示踪剂对非前列腺癌进行成像：基本原理、当前领域状况和行动呼吁。
J Nucl Med. 2018 Jun;59(6):871-877. doi: 10.2967/jnumed.117.203570. Epub 2018 Mar 15.
4
Metastases From Colorectal Cancer Avid on 68Ga-PSMA PET/CT.68Ga-PSMA PET/CT 摄取的结直肠癌转移灶。
Clin Nucl Med. 2017 Jul;42(7):532-533. doi: 10.1097/RLU.0000000000001700.
5
Rectal Carcinoma on 68Ga-PSMA PET/CT.68Ga-PSMA PET/CT 所见直肠癌。
Clin Nucl Med. 2016 Mar;41(3):e167-8. doi: 10.1097/RLU.0000000000001072.

用于检测 PSMA 阳性转移性结直肠癌的放射性药物：18F-BF3-Cy3-ACUPA 和 68Ga-PSMA PET/MRI 的配对比较。

Radiopharmaceutical for detecting PSMA - positive metastatic colon cancer: Matched-pair comparison of 18F-BF3-Cy3-ACUPA and 68Ga-PSMA PET/MRI.

机构信息

Departament of Radiology, Memorial Sloan Kettering Cancer Center, New York, United States.

Department of Urology, Cerrahpasa Medical Faculty, Istanbul, Turkey.

出版信息

Nucl Med Rev Cent East Eur. 2022;25(2):129-130. doi: 10.5603/NMR.a2022.0027. Epub 2022 Jun 14.

DOI:10.5603/NMR.a2022.0027
PMID:35699591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9878462/
Abstract

Prostate-specific membrane antigen (PSMA) - based radiopharmaceuticals are promising for the evaluation of PSMA-positive non-prostate cancers. In this case study, 18F-BF3-Cy3-ACUPA and 68Ga-PSMA positron emission tomography/magnetic resonance imaging (PET/MRI) were compared in a patient with metastatic colon cancer. Both 18F-BF3-Cy3-ACUPA and 68Ga-PSMA PET/MRI showed biopsy-proven metastatic left external iliac adenopathy, highlighting the feasibility of PSMA uptake in PET/MRI of metastatic nodal disease from colon cancer. Along with imaging evaluation, PSMA-based radiopharmaceuticals may also be used as a surrogate imaging tracer for potential theranostic applications using alpha or beta emitters in the context of PSMA-directed radiopharmaceutical therapy in advanced and progressive colorectal cancer.

摘要

前列腺特异性膜抗原（PSMA）为基础的放射性药物在评估 PSMA 阳性非前列腺癌方面具有广阔的应用前景。在本病例研究中，比较了 18F-BF3-Cy3-ACUPA 和 68Ga-PSMA 正电子发射断层扫描/磁共振成像（PET/MRI）在转移性结肠癌患者中的应用。18F-BF3-Cy3-ACUPA 和 68Ga-PSMA PET/MRI 均显示活检证实的转移性左侧髂外淋巴结病变，突出了 PSMA 在转移性结直肠癌淋巴结疾病 PET/MRI 中的摄取的可行性。除了影像学评估外，PSMA 放射性药物还可以作为一种替代成像示踪剂，用于潜在的治疗应用，包括使用α或β发射体，这在 PSMA 导向的放射性药物治疗晚期和进展性结直肠癌中具有重要意义。