用于检测 PSMA 阳性转移性结直肠癌的放射性药物：18F-BF3-Cy3-ACUPA 和 68Ga-PSMA PET/MRI 的配对比较。

Radiopharmaceutical for detecting PSMA - positive metastatic colon cancer: Matched-pair comparison of 18F-BF3-Cy3-ACUPA and 68Ga-PSMA PET/MRI.

机构信息

Departament of Radiology, Memorial Sloan Kettering Cancer Center, New York, United States.

Department of Urology, Cerrahpasa Medical Faculty, Istanbul, Turkey.

出版信息

Nucl Med Rev Cent East Eur. 2022;25(2):129-130. doi: 10.5603/NMR.a2022.0027. Epub 2022 Jun 14.

DOI:10.5603/NMR.a2022.0027

PMID:35699591

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9878462/

Abstract

Prostate-specific membrane antigen (PSMA) - based radiopharmaceuticals are promising for the evaluation of PSMA-positive non-prostate cancers. In this case study, 18F-BF3-Cy3-ACUPA and 68Ga-PSMA positron emission tomography/magnetic resonance imaging (PET/MRI) were compared in a patient with metastatic colon cancer. Both 18F-BF3-Cy3-ACUPA and 68Ga-PSMA PET/MRI showed biopsy-proven metastatic left external iliac adenopathy, highlighting the feasibility of PSMA uptake in PET/MRI of metastatic nodal disease from colon cancer. Along with imaging evaluation, PSMA-based radiopharmaceuticals may also be used as a surrogate imaging tracer for potential theranostic applications using alpha or beta emitters in the context of PSMA-directed radiopharmaceutical therapy in advanced and progressive colorectal cancer.

摘要

前列腺特异性膜抗原（PSMA）为基础的放射性药物在评估 PSMA 阳性非前列腺癌方面具有广阔的应用前景。在本病例研究中，比较了 18F-BF3-Cy3-ACUPA 和 68Ga-PSMA 正电子发射断层扫描/磁共振成像（PET/MRI）在转移性结肠癌患者中的应用。18F-BF3-Cy3-ACUPA 和 68Ga-PSMA PET/MRI 均显示活检证实的转移性左侧髂外淋巴结病变，突出了 PSMA 在转移性结直肠癌淋巴结疾病 PET/MRI 中的摄取的可行性。除了影像学评估外，PSMA 放射性药物还可以作为一种替代成像示踪剂，用于潜在的治疗应用，包括使用α或β发射体，这在 PSMA 导向的放射性药物治疗晚期和进展性结直肠癌中具有重要意义。

相似文献

Radiopharmaceutical for detecting PSMA - positive metastatic colon cancer: Matched-pair comparison of 18F-BF3-Cy3-ACUPA and 68Ga-PSMA PET/MRI.用于检测 PSMA 阳性转移性结直肠癌的放射性药物：18F-BF3-Cy3-ACUPA 和 68Ga-PSMA PET/MRI 的配对比较。

Nucl Med Rev Cent East Eur. 2022;25(2):129-130. doi: 10.5603/NMR.a2022.0027. Epub 2022 Jun 14.

Small Molecule, Multimodal, [F]-PET and Fluorescence Imaging Agent Targeting Prostate-Specific Membrane Antigen: First-in-Human Study.小分子、多模式、[F]-PET 和荧光成像剂靶向前列腺特异性膜抗原：首例人体研究。

Clin Genitourin Cancer. 2021 Oct;19(5):405-416. doi: 10.1016/j.clgc.2021.03.011. Epub 2021 Mar 19.

More advantages in detecting bone and soft tissue metastases from prostate cancer using F-PSMA PET/CT.使用F-PSMA PET/CT检测前列腺癌骨和软组织转移方面有更多优势。

Hell J Nucl Med. 2019 Jan-Apr;22(1):6-9. doi: 10.1967/s002449910952. Epub 2019 Mar 7.

How accurate is Gallium-prostate specific membrane antigen positron emission tomography / computed tomography (Ga-PSMA PET/CT) on primary lymph node staging before radical prostatectomy in intermediate and high risk prostate cancer? A study of patient- and lymph node- based analyses.镓-前列腺特异性膜抗原正电子发射断层扫描/计算机断层扫描（Ga-PSMA PET/CT）在中高危前列腺癌根治性前列腺切除术前对原发性淋巴结分期的准确性如何？一项基于患者和淋巴结的分析研究。

Urol Oncol. 2022 Jan;40(1):6.e1-6.e9. doi: 10.1016/j.urolonc.2021.07.006. Epub 2021 Aug 13.

PET/CT With Ga-PSMA in Prostate Cancer: Radiopharmaceutical Background and Clinical Implications.前列腺癌中使用镓-前列腺特异性膜抗原的正电子发射断层扫描/计算机断层扫描：放射性药物背景及临床意义

Curr Radiopharm. 2018;11(1):4-13. doi: 10.2174/1874471010666171101121803.

Primary lymph-node staging with Ga-PSMA PET in high-risk prostate cancer: pathologic correlation with extended pelvic lymphadenectomy specimens.高危前列腺癌中 Ga-PSMA PET 进行初级淋巴结分期：与扩大盆腔淋巴结清扫标本的病理相关性。

Urol Oncol. 2021 Aug;39(8):494.e1-494.e6. doi: 10.1016/j.urolonc.2020.10.074. Epub 2020 Nov 19.

Clin Nucl Med. 2022 Jul 1;47(7):575-582. doi: 10.1097/RLU.0000000000004190. Epub 2022 Apr 27.

New Clinical Indications for (18)F/(11)C-choline, New Tracers for Positron Emission Tomography and a Promising Hybrid Device for Prostate Cancer Staging: A Systematic Review of the Literature.（18）F/（11）C-胆碱的新临床适应证、正电子发射断层扫描的新型示踪剂和用于前列腺癌分期的有前途的混合设备：文献系统评价。

Eur Urol. 2016 Jul;70(1):161-175. doi: 10.1016/j.eururo.2016.01.029. Epub 2016 Feb 2.

Accuracy of 68Ga-PSMA PET-CT and PET-MRI in lymph node staging for localized prostate cancer.68Ga-PSMA PET-CT 和 PET-MRI 在局部前列腺癌淋巴结分期中的准确性。

Einstein (Sao Paulo). 2022 May 16;20:eAO6599. doi: 10.31744/einstein_journal/2022AO6599. eCollection 2022.

A randomised, prospective and head-to-head comparison of [68Ga]Ga-PSMA-11 and [18F]PSMA-1007 for the detection of recurrent prostate cancer in PSMA-ligand PET/CT-Protocol design and rationale.一项针对[68Ga]Ga-PSMA-11 和 [18F]PSMA-1007 在 PSMA 配体 PET/CT 中用于检测复发性前列腺癌的随机、前瞻性、头对头比较的方案设计和原理。

PLoS One. 2022 Jul 19;17(7):e0270269. doi: 10.1371/journal.pone.0270269. eCollection 2022.

本文引用的文献

Simultaneous injection of F-BF3- Cy3-ACUPA and non-radioactive Cy7-ACUPA probes: a promising pre-biopsy PET and ex vivo fluorescence imaging approach to evaluate prostate cancer.

Eur J Nucl Med Mol Imaging. 2021 Oct;48(11):3732-3733. doi: 10.1007/s00259-021-05344-w. Epub 2021 Apr 16.

PET Imaging Quantifying Ga-PSMA-11 Uptake in Metastatic Colorectal Cancer.正电子发射断层扫描（PET）成像定量检测转移性结直肠癌中 Ga-PSMA-11 的摄取。

J Nucl Med. 2020 Nov;61(11):1576-1579. doi: 10.2967/jnumed.119.233312. Epub 2020 May 1.

Imaging of Nonprostate Cancers Using PSMA-Targeted Radiotracers: Rationale, Current State of the Field, and a Call to Arms.使用 PSMA 靶向放射性示踪剂对非前列腺癌进行成像：基本原理、当前领域状况和行动呼吁。

J Nucl Med. 2018 Jun;59(6):871-877. doi: 10.2967/jnumed.117.203570. Epub 2018 Mar 15.

Metastases From Colorectal Cancer Avid on 68Ga-PSMA PET/CT.68Ga-PSMA PET/CT 摄取的结直肠癌转移灶。

Clin Nucl Med. 2017 Jul;42(7):532-533. doi: 10.1097/RLU.0000000000001700.

Rectal Carcinoma on 68Ga-PSMA PET/CT.68Ga-PSMA PET/CT 所见直肠癌。

Clin Nucl Med. 2016 Mar;41(3):e167-8. doi: 10.1097/RLU.0000000000001072.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验