Post Graduation Program in Dentistry, Universidade Federal da Paraíba (UFPB), Campus I - Cidade Universitária, João Pessoa, Paraíba 58033-455, Brazil.
Universidad Autónoma de Nuevo León, Mexico.
J Stomatol Oral Maxillofac Surg. 2022 Nov;123(6):e757-e759. doi: 10.1016/j.jormas.2022.06.003. Epub 2022 Jun 11.
This paper aims to discuss clinical aspects of mucormycosis. This case series was conducted in two services, comprising six mucormycosis cases during COVID-19 pandemic. About gender, there are 4 (66.7%) males and 2 (33.3%) females with mean age (48.7 ± 9.4) years. All cases presented complaints of pain and swelling in oral cavity and had an aggressive clinical presentation. Five patients had diabetes and one had a nasal non-Hodgkin lymphoma. Histologically, large, branched, hyphae associated with necrotic areas were observed, confirming microscopically such as mucormycosis through PAS and GMS stains. In four cases, treatment consisted in surgical debridement associated with antifungal therapy. All patients were submitted to debridement and received antifungal treatment (amphotericin B). Five patients were followed up without clinical recurrence, but unfortunately one patient died. Diagnosis of mucormycosis should be early because it is related to high mortality. The treatment consists of surgical debridement associated with antifungal therapy.
本文旨在讨论毛霉病的临床方面。本病例系列研究在两个科室进行，共纳入 COVID-19 大流行期间的 6 例毛霉病病例。关于性别，有 4 例（66.7%）男性和 2 例（33.3%）女性，平均年龄（48.7±9.4）岁。所有病例均表现出口腔疼痛和肿胀，并呈侵袭性临床表现。5 例患者患有糖尿病，1 例患有鼻非霍奇金淋巴瘤。组织学上，观察到与坏死区相关的大型、分支状菌丝，通过 PAS 和 GMS 染色微观上证实为毛霉病。4 例患者接受了手术清创术联合抗真菌治疗。所有患者均接受清创术和抗真菌治疗（两性霉素 B）。5 例患者无临床复发，随访，但不幸的是，1 例患者死亡。毛霉病的诊断应尽早进行，因为它与高死亡率有关。治疗包括手术清创术联合抗真菌治疗。
