使用金鸡纳生物碱衍生的NNP配体对芳香族和杂芳香族酮进行钌催化的不对称氢化反应。
Ruthenium-catalyzed asymmetric hydrogenation of aromatic and heteroaromatic ketones using cinchona alkaloid-derived NNP ligands.
作者信息
Zhang Ling, Chen Qian, Li Linlin, Jiang Jian, Sun Hao, Li Li, Liu Ting, Zhang Lin, Li Chun
机构信息
State Key Laboratory of Functions and Applications of Medicinal Plants & School of Pharmaceutical Sciences, Guizhou Medical University 550004 Guiyang China
出版信息
RSC Adv. 2022 May 18;12(23):14912-14916. doi: 10.1039/d2ra02211g. eCollection 2022 May 12.
A series of cinchona alkaloid-based NNP ligands, including a new one, have been employed for the asymmetric hydrogenation of ketones. By combining ruthenium complexes, various aromatic and heteroaromatic ketones were smoothly reacted, yielding valuable chiral alcohols with extremely high 99.9% ee. Moreover, a proposed reaction mechanism was discussed and verified by NMR.
一系列基于金鸡纳生物碱的NNP配体，包括一种新的配体，已被用于酮的不对称氢化反应。通过与钌配合物相结合，各种芳香族和杂芳香族酮都能顺利反应，生成具有极高99.9%对映体过量（ee）的有价值的手性醇。此外，还通过核磁共振（NMR）对提出的反应机理进行了讨论和验证。
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