College of Chemistry and Molecular Sciences, Wuhan University , Wuhan, Hubei 430072, P. R. China.
Department of Chemistry and Chemical Biology & Department of Pharmaceutical Chemistry, Rutgers, The State University of New Jersey , Piscataway, New Jersey 08854, United States.
Org Lett. 2016 Jun 17;18(12):2938-41. doi: 10.1021/acs.orglett.6b01290. Epub 2016 Jun 3.
A series of modular and rich electronic tridentate ferrocene aminophosphoxazoline ligands (f-amphox) have been successfully developed and used in iridium-catalytic asymmetric hydrogenation of simple ketones to afford corresponding enantiomerically enriched alcohols under mild conditions with superb activities and excellent enantioselectivities (up to 1 000 000 TON, almost all products up to >99% ee, full conversion). The resulting chiral alcohols and their derivatives are important intermediates in pharmaceuticals.
一系列模块化的、丰富的三齿电子型二茂铁氨基膦恶唑啉配体（f-amphox）已被成功开发并应用于简单酮的铱催化不对称氢化反应中，在温和条件下以优异的活性和对映选择性（高达 1 000 000 TON，几乎所有产物的对映体过量值都高达 >99%，转化率 100%）得到相应的对映体富集醇。所得的手性醇及其衍生物是药物中的重要中间体。
