Sari Agnes Rosarina Prita, Puspitasari Monika, Soebono Hardyanto, Trisnowati Niken
Department of Dermatology and Venereology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Dr. Sardjito General Hospital, Yogyakarta, Indonesia.
Case Rep Dermatol. 2022 May 9;14(2):107-111. doi: 10.1159/000524466. eCollection 2022 May-Aug.
A 51-year-old man came to the dermatology and venereology outpatient clinic with the complaint of multiple itchy lumps on his body. The patient had a previous history of hemodialysis due to end-stage renal disease. He also had a previous history of hepatitis B, an abnormal liver function test, and high blood sugar. Histopathological examination with Masson's trichrome revealed that the patient had extrusion collagen in the epidermis which had invagination. Acquired perforating disorder is frequently misdiagnosed as other skin diseases, thus this condition is underdiagnosed. In addition, underlying diseases frequently associated with acquired perforating collagenosis are chronic kidney disease, hepatic insufficiency, and diabetes mellitus. The patient in this case had all 3 conditions. Further investigation is needed to determine whether acquired perforating disorder with multiple underlying diseases will have similar severity with single underlying disease.
一名51岁男性因身上出现多处瘙痒性肿块前往皮肤科和性病门诊就诊。该患者既往有终末期肾病导致的血液透析史。他还曾有乙型肝炎病史、肝功能检查异常和高血糖病史。经Masson三色染色的组织病理学检查显示，患者表皮有内陷的挤压性胶原。获得性穿通性疾病常被误诊为其他皮肤病，因此这种情况诊断不足。此外，与获得性穿通性胶原病常相关的基础疾病是慢性肾病、肝功能不全和糖尿病。该病例中的患者具备所有这三种情况。需要进一步研究以确定患有多种基础疾病的获得性穿通性疾病是否会与单一基础疾病具有相似的严重程度。
