早期癫痫发作对认知和运动发育的影响：病例系列研究。

The Effect of Early-Life Seizures on Cognitive and Motor Development: A Case Series.

机构信息

Department of Physical Therapy (Dr Willett), Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, Nebraska; Department of Physical Therapy (Drs Cunha and Lobo), Biomechanics and Movement Science Program, University of Delaware, Newark, Delaware; Department of Physical Therapy (Dr Harbourne), Duquesne University, Pittsburgh, Pennsylvania; Division of Biokinesiology and Physical Therapy (Dr Dusing), University of Southern California, Los Angeles CA; Department of Rehabilitation Medicine (Drs Westcott-McCoy and Hsu), University of Washington, Seattle, Washington; Nebraska Center for Research on Children, Youth, Families and Schools (Drs Koziol and Bovaird), University of Nebraska-Lincoln, Lincoln, Nebraska; College of Human Science and Education (Dr Marcinowski), Louisiana State University, Baton Rouge, Louisiana; Department of Psychological Science (Dr Babik), Boise State University, Boise, Idaho; Department of Physical Therapy (Dr An), Kaya University, Gimhae-si, Gyeongsangnam-do, Republic of Korea.

出版信息

Pediatr Phys Ther. 2022 Jul 1;34(3):425-431. doi: 10.1097/PEP.0000000000000918. Epub 2022 Jun 8.

DOI:10.1097/PEP.0000000000000918

PMID:35703307

Abstract

PURPOSE

This case series documents developmental changes over time and in response to a novel intervention, Sitting Together and Reaching to Play (START-Play), in children with early-life seizures.

METHODS

Thirteen children with early-life seizures were included from a subset of participants in the START-Play multisite, randomized controlled trial. Seven received 3 months of twice weekly START-Play intervention; 6 continued with usual care early intervention. Bayley Scales of Infant Development-III (Cognitive Composite), Gross Motor Function Measure-66 Item Set, Assessment of Problem-Solving in Play, and reaching assessments were administered at baseline, 3, 6, and 12 months postbaseline. Change scores are reported at 3 and 12 months postbaseline.

RESULTS

Over time, plateau or decline was noted in standardized cognition measures; motor development improved or was stable. Children receiving START-Play showed positive trends in problem-solving (71.4%) and reaching behaviors (57.2%).

CONCLUSIONS

Interventions such as START-Play that combine motor and cognitive constructs may benefit children with early-life seizures.

摘要

目的

本病例系列研究记录了患有婴幼儿期癫痫的儿童随时间推移和对新型干预措施“坐立共玩”（START-Play）的反应而发生的发育变化。

方法

本研究纳入了 START-Play 多中心随机对照试验的部分参与者中的 13 名婴幼儿期癫痫患儿。其中 7 名患儿接受了为期 3 个月、每周 2 次的 START-Play 干预；6 名患儿继续接受常规早期干预。在基线、3、6 和 12 个月时进行贝利婴幼儿发展量表第三版（认知综合评分）、粗大运动功能测量-66 项测试、游戏问题解决评估和伸手评估。在基线后 3 个月和 12 个月时报告变化评分。