Department of Pediatric Dentistry, Faculty of Dentistry, Karadeniz Technical University, Trabzon, Turkey.
Department of Prosthodontics, Faculty of Dentistry, Karadeniz Technical University, Trabzon, Turkey.
Dent Med Probl. 2022 Apr-Jun;59(2):225-231. doi: 10.17219/dmp/133406.
Changes in the color of the teeth are a common dental finding associated with clinical and esthetic problems. Especially, the discoloration of primary teeth can cause parental concern and have a negative effect on social interactions between preschool children.
The aim of the study was to evaluate the effect of pediatric drugs and an oral rinse on the discoloration of primary teeth.
Similar to medication intake recommendations, 7 primary teeth in each group were immersed for 1 min in one of 11 different solutions at 8-hour intervals for 1 week. The color values were obtained using a spectrophotometer (VITA EasyShade®) at baseline and after 1 week. The color change (ΔE*) values were calculated according to the CIELab system. The statistical analysis was conducted using the one-way analysis of variance (ANOVA) and Tukey's post hoc tests at a p-value <0.05.
When comparing values L*, a* and b* at baseline and day 7, a statistically significant difference was found in the a* value for the teeth immersed in pseudoephedrine (p = 0.012). There were also statistically significant differences with regard to color change at day 7 (ΔE*7) between the pseudoephedrine and chlorhexidine as well as pseudoephedrine and control groups (p = 0.034 and p = 0.030, respectively).
The ΔE*7 value for pseudoephedrine was 3.7 after 1 week, indicating that it may have the potential to cause significant tooth discoloration when used for a long period. Clinicians and children's families should be aware of the fact that some pediatric drugs can cause tooth discoloration.
牙齿颜色的变化是一种常见的口腔发现，与临床和美观问题有关。特别是，乳牙的变色会引起家长的关注，并对学龄前儿童之间的社交互动产生负面影响。
本研究旨在评估儿科药物和漱口液对乳牙变色的影响。
类似于药物摄入建议，每组中的 7 颗乳牙在 8 小时的间隔内，将每颗乳牙在 11 种不同溶液中的一种中浸泡 1 分钟，持续 1 周。使用分光光度计（VITA EasyShade®）在基线和 1 周后获得颜色值。根据 CIELab 系统计算颜色变化值（ΔE*）。使用单向方差分析（ANOVA）和 Tukey 事后检验进行统计分析，p 值<0.05。
当比较基线和第 7 天的 L*、a和 b值时，伪麻黄碱浸泡的牙齿的 a值存在统计学差异（p=0.012）。在第 7 天的颜色变化（ΔE7）方面，伪麻黄碱与洗必泰和伪麻黄碱与对照组之间也存在统计学差异（p=0.034 和 p=0.030）。
伪麻黄碱在第 1 周后 7 的 ΔE*7 值为 3.7，表明其在长期使用时可能具有导致牙齿显著变色的潜力。临床医生和儿童的家庭应该意识到一些儿科药物可能会导致牙齿变色。
