Kurt Nezahat, Ozgeris Fatma Betul, Volkan Burcu, Gul Mehmet Ali, Cayir Atilla
Departman of Medical Biochemistry, Faculty of Medicine, Erzincan Binali Yildirim University, Turkey.
Departman of Nutrition and Dietetics, Faculty of Healthy Sciences, Ataturk University, Turkey.
Eurasian J Med. 2022 Jun;54(2):186-190. doi: 10.5152/eurasianjmed.2022.21293.
Fetuin-A is a multifunctional non-collagen protein that plays a role in bone mineralization. Celiac disease is a chronic inflammatory disorder of the small intestine due to exposure to gluten. In this research, it was aimed to investigate levels of Fetuin-A and its relationship with bone mineral density in children with celiac disease.
The study was conducted on 59 children with celiac and 29 healthy children. The celiac disease group was composed of three groups, newly diagnosed, gluten-free diet compliant and, non- gluten- free diet compliant patients. Serum Fetuin-A concentrations were measured by an enzyme-linked immuno- sorbent assay kit. Measurement of bone mineral density was performed a dual-energy x-ray absorptiometry.
Serum Fetuin-A levels were 136.85 ± 38.09 μg/L and 112.95 ± 44.39 μg/L in the celiac disease and healthy control groups, respectively. There was a statistically significant difference between groups in levels of serum Fetuin-A (P < .05). A significant positive correlation was observed between serum Fetuin-A and bone mineral density Z-score in the celiac patients.
Increased Fetuin-A levels and positive correlation between Fetuin-A and bone mineral density in children with celiac disease suggest that Fetuin-A may be a biomarker for celiac disease.
胎球蛋白-A是一种多功能非胶原蛋白，在骨矿化过程中发挥作用。乳糜泻是一种由于接触麸质而引起的小肠慢性炎症性疾病。本研究旨在调查乳糜泻患儿的胎球蛋白-A水平及其与骨密度的关系。
该研究对59名乳糜泻患儿和29名健康儿童进行。乳糜泻组由三组组成，即新诊断的、遵循无麸质饮食的和不遵循无麸质饮食的患者。采用酶联免疫吸附测定试剂盒测量血清胎球蛋白-A浓度。使用双能X线吸收法测量骨密度。
乳糜泻组和健康对照组的血清胎球蛋白-A水平分别为136.85±38.09μg/L和112.95±44.39μg/L。两组血清胎球蛋白-A水平存在统计学显著差异（P<.05）。在乳糜泻患者中，血清胎球蛋白-A与骨密度Z评分之间存在显著正相关。
乳糜泻患儿胎球蛋白-A水平升高以及胎球蛋白-A与骨密度之间呈正相关，提示胎球蛋白-A可能是乳糜泻的生物标志物。
