Laboratório de Ciências do Exercício, Departamento de Fisiologia e Farmacologia, Universidade Federal Fluminense, Niterói, RJ, Brasil.
Laboratório de Bioengenharia e Toxicologia in Vitro, Instituto Nacional de Qualidade e Tecnologia Metrológica, Duque de Caxias, RJ, Brasil.
Braz J Med Biol Res. 2022 Jun 13;55:e12110. doi: 10.1590/1414-431X2022e12110. eCollection 2022.
In preparation for tracheal intubation during induction of anesthesia, the patient may be ventilated with 100% oxygen. To investigate the impact of acute isocapnic hyperoxia on endothelial activation and vascular remodeling, ten healthy young men (24±3 years) were exposed to 5-min normoxia (21% O2) and 10-min hyperoxia trials (100% O2). During hyperoxia, intercellular adhesion molecules (ICAM-1) (hyperoxia: 4.16±0.85 vs normoxia: 3.51±0.84 ng/mL, P=0.04) and tissue inhibitor matrix metalloproteinase 1 (TIMP-1) (hyperoxia: 8.40±3.84 vs normoxia: 5.73±2.15 pg/mL, P=0.04) increased, whereas matrix metalloproteinase (MMP-9) activity (hyperoxia: 0.53±0.11 vs normoxia: 0.68±0.18 A.U., P=0.03) decreased compared to the normoxia trial. We concluded that even short exposure to 100% oxygen may affect endothelial activation and vascular remodeling.
在麻醉诱导期间进行气管插管准备时，患者可能会接受 100%氧气通气。为了研究急性等碳酸高氧对血管内皮细胞激活和血管重塑的影响，10 名健康年轻男性（24±3 岁）接受了 5 分钟常氧（21% O2）和 10 分钟高氧试验（100% O2）。在高氧期间，细胞间黏附分子（ICAM-1）（高氧：4.16±0.85 与常氧：3.51±0.84ng/mL，P=0.04）和组织抑制剂基质金属蛋白酶 1（TIMP-1）（高氧：8.40±3.84 与常氧：5.73±2.15pg/mL，P=0.04）增加，而基质金属蛋白酶（MMP-9）活性（高氧：0.53±0.11 与常氧：0.68±0.18A.U.，P=0.03）与常氧试验相比降低。我们得出结论，即使短暂暴露于 100%氧气也可能影响内皮细胞激活和血管重塑。
