Department of Surgery, Minimally Invasive Surgery Research Center, Division of Minimally Invasive and Bariatric Surgery, Rasool-E Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Whittington Hospital, London, UK.
Obes Surg. 2022 Aug;32(8):2512-2524. doi: 10.1007/s11695-022-06124-7. Epub 2022 Jun 15.
One anastomosis/mini gastric bypass (OAGB/MGB) is up to date the third most performed obesity and metabolic procedure worldwide, which recently has been endorsed by ASMBS. The main criticisms are the risk of bile reflux, esophageal cancer, and malnutrition. Although IFSO has recognized this procedure, guidance is needed regarding selection criteria. To give clinicians a daily support in performing the right patient selection in OAGB/MGB, the aim of this paper is to generate clinical guidelines based on an expert modified Delphi consensus.
A committee of 57 recognized bariatric surgeons from 24 countries created 69 statements. Modified Delphi consensus voting was performed in two rounds. An agreement/disagreement among ≥ 70.0% of the experts was considered to indicate a consensus.
Consensus was achieved for 56 statements. Remarkably, ≥ 90.0% of the experts felt that OAGB/MGB is an acceptable and suitable option "in patients with Body mass index (BMI) > 70, BMI > 60, BMI > 50 kg/m as a one-stage procedure," "as the second stage of a two-stage bariatric surgery after Sleeve Gastrectomy for BMI > 50 kg/m (instead of BPD/DS)," and "in patients with weight regain after restrictive procedures. No consensus was reached on the statement that OAGB/MGB is a suitable option in case of resistant Helicobacter pylori. This is likely as there is a concern that this procedure is associated with reflux and its related long-term complications including risk of cancer in the esophagus or stomach. Also no consensus reached on OAGB/MGB as conversional surgery in patients with GERD after restrictive procedures. Consensus for disagreement was predominantly achieved "in case of intestinal metaplasia of the stomach" (74.55%), "in patients with severe Gastro Esophageal Reflux Disease (GERD)(C,D)" (75.44%), "in patients with Barrett's metaplasia" (89.29%), and "in documented insulinoma" (89.47%).
Patient selection in OAGB/MGB is still a point of discussion among experts. There was consensus that OAGB/MGB is a suitable option in elderly patients, patients with low BMI (30-35 kg/m) with associated metabolic problems, and patients with BMIs more than 50 kg/m as one-stage procedure. OAGB/MGB can also be a safe procedure in vegetarian and vegan patients. Although OAGB/MGB can be a suitable procedure in patients with large hiatal hernia with concurrent hiatal hernia, it should not be offered to patients with grade C or D esophagitis or Barrett's metaplasia.
单吻合口胃旁路术(OAGB/MGB)是目前全球第三大肥胖和代谢手术,最近已被 ASMBS 认可。主要的批评是胆汁反流、食管癌和营养不良的风险。尽管 IFSO 已经认识到了这种手术,但在选择标准方面仍需要指导。为了在 OAGB/MGB 中为临床医生提供日常支持,以便对合适的患者进行选择,本文旨在基于专家修改后的 Delphi 共识制定临床指南。
来自 24 个国家的 57 名公认的减重外科医生组成的委员会提出了 69 项声明。在两轮投票中进行了 Delphi 共识投票。专家们达成的协议/分歧共识≥70.0%表示达成共识。
56 项声明达成共识。值得注意的是,≥90.0%的专家认为 OAGB/MGB 是一种可接受和合适的选择,“适用于 BMI>70、BMI>60、BMI>50kg/m2的患者,作为单阶段手术”,“作为袖状胃切除术后 BMI>50kg/m2(而不是 BPD/DS)的两阶段减重手术的第二阶段”,以及“在限制性手术后体重增加的患者中。对于 OAGB/MGB 在耐药性幽门螺杆菌感染的情况下是否是合适的选择,未达成共识。这可能是因为人们担心这种手术与反流及其相关的长期并发症有关,包括食管或胃的癌症风险。对于限制性手术后胃食管反流病(GERD)患者,OAGB/MGB 作为转化手术也没有达成共识。对于“在胃的肠上皮化生”(74.55%)、“在严重胃食管反流病(GERD)(C、D)患者中”(75.44%)、“在 Barrett 化生患者中”(89.29%)和“在有记录的胰岛素瘤患者中”(89.47%),达成了主要是不一致的共识。
OAGB/MGB 中的患者选择仍然是专家们讨论的一个问题。专家们一致认为,OAGB/MGB 是老年患者、BMI(30-35kg/m)较低伴发代谢问题的患者以及 BMI 超过 50kg/m 的患者的一种合适选择,也可作为单阶段手术。素食主义和纯素食主义者也可以进行 OAGB/MGB 手术。尽管 OAGB/MGB 可以作为伴有并发食管裂孔疝的大食管裂孔疝患者的安全手术,但不应该为患有 C 级或 D 级食管炎或 Barrett 化生的患者提供这种手术。