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Misbehaving Guests in the Right Ventricle: Macrophage-NLRP3 Activation in Pulmonary Hypertension.

作者信息

Fais Rafael Sobrano, Lahm Tim

机构信息

Division of Pulmonary, Sleep, and Critical Care Medicine National Jewish Health Denver, Colorado.

University of Colorado Anschutz Medical Campus Aurora, Colorado.

出版信息

Am J Respir Crit Care Med. 2022 Sep 1;206(5):532-534. doi: 10.1164/rccm.202205-0977ED.

DOI:10.1164/rccm.202205-0977ED
PMID:35704289
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9716905/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c6/9716905/15cb97b3782d/rccm.202205-0977EDf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c6/9716905/15cb97b3782d/rccm.202205-0977EDf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c6/9716905/15cb97b3782d/rccm.202205-0977EDf1.jpg

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本文引用的文献

1
Macrophage-NLRP3 Activation Promotes Right Ventricle Failure in Pulmonary Arterial Hypertension.巨噬细胞-NLRP3 激活促进肺动脉高压中的右心衰竭。
Am J Respir Crit Care Med. 2022 Sep 1;206(5):608-624. doi: 10.1164/rccm.202110-2274OC.
2
Inflammasome Activation in Pulmonary Arterial Hypertension.肺动脉高压中的炎性小体激活
Front Med (Lausanne). 2022 Jan 13;8:826557. doi: 10.3389/fmed.2021.826557. eCollection 2021.
3
Pyroptosis: mechanisms and diseases.细胞焦亡：机制与疾病。
Signal Transduct Target Ther. 2021 Mar 29;6(1):128. doi: 10.1038/s41392-021-00507-5.
4
Structure, Activation and Regulation of NLRP3 and AIM2 Inflammasomes.NLRP3 和 AIM2 炎性小体的结构、激活和调控。
Int J Mol Sci. 2021 Jan 16;22(2):872. doi: 10.3390/ijms22020872.
5
Implication of Potassium Channels in the Pathophysiology of Pulmonary Arterial Hypertension.钾通道在肺动脉高压发病机制中的意义。
Biomolecules. 2020 Sep 1;10(9):1261. doi: 10.3390/biom10091261.
6
Sex Differences in Right Ventricular-Pulmonary Arterial Coupling in Pulmonary Arterial Hypertension.肺动脉高压中右心室-肺动脉耦联的性别差异
Am J Respir Crit Care Med. 2020 Oct 1;202(7):1042-1046. doi: 10.1164/rccm.202003-0807LE.
7
Targeting NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome in Cardiovascular Disorders.靶向 NLRP3（核苷酸结合域、富含亮氨酸重复序列、含pyrin 结构域蛋白 3）炎症小体治疗心血管疾病。
Arterioscler Thromb Vasc Biol. 2018 Dec;38(12):2765-2779. doi: 10.1161/ATVBAHA.118.311916.
8
IL-1 Blockade Reduces Inflammation in Pulmonary Arterial Hypertension and Right Ventricular Failure: A Single-Arm, Open-Label, Phase IB/II Pilot Study.白细胞介素-1阻断可减轻肺动脉高压和右心室衰竭中的炎症：一项单臂、开放标签的1B/II期试点研究。
Am J Respir Crit Care Med. 2019 Feb 1;199(3):381-384. doi: 10.1164/rccm.201809-1631LE.
9
Assessment of Right Ventricular Function in the Research Setting: Knowledge Gaps and Pathways Forward. An Official American Thoracic Society Research Statement.研究环境下心功能右心室评估：知识空白与前进道路。美国胸科学会官方研究声明。
Am J Respir Crit Care Med. 2018 Aug 15;198(4):e15-e43. doi: 10.1164/rccm.201806-1160ST.
10
The human heart contains distinct macrophage subsets with divergent origins and functions.人类心脏中存在具有不同起源和功能的独特巨噬细胞亚群。
Nat Med. 2018 Aug;24(8):1234-1245. doi: 10.1038/s41591-018-0059-x. Epub 2018 Jun 11.