Hede S S, Diniz R S, Agshikar N V, Dhume V G
Indian J Physiol Pharmacol. 1986 Oct-Dec;30(4):322-8.
Effect of zinc sulphate was studied on histamine-induced contractions on guinea-pig ileum. In doses of 1.72 X 10(-7)M or less no effects were observed. Zinc sulphate in doses of 3.44 X 10(-7)M, 6.88 X 10(-7)M and 1.72 X 10(-6)M produced dual effect. Short exposure of tissue for 10 min to zinc sulphate resulted in significant dose dependent potentiation of histamine effect whereas after washing the tissue of zinc sulphate, histamine response was inhibited significantly and in a dose dependent manner. Higher concentrations of zinc sulphate of 3.44 X 10(-6)M and above produced irreversible inhibition of histamine response. The above observations have been explained in terms of zinc-calcium interaction. It is hypothesized that interaction of zinc with calcium may take place extracellularly at membrane level and intracellularly.
研究了硫酸锌对组胺诱导的豚鼠回肠收缩的影响。剂量为1.72×10⁻⁷M或更低时未观察到影响。剂量为3.44×10⁻⁷M、6.88×10⁻⁷M和1.72×10⁻⁶M的硫酸锌产生双重效应。将组织短时间（10分钟）暴露于硫酸锌会导致组胺效应显著的剂量依赖性增强，而在冲洗掉组织中的硫酸锌后，组胺反应受到显著抑制且呈剂量依赖性。浓度高于3.44×10⁻⁶M的硫酸锌会对组胺反应产生不可逆抑制。上述观察结果已根据锌 - 钙相互作用进行了解释。据推测，锌与钙的相互作用可能发生在细胞外的膜水平以及细胞内。
