自闭症谱系障碍的母婴及新生儿危险因素：来自埃及的病例对照研究。

Maternal and neonatal risk factors for autism spectrum disorder: A case-control study from Egypt.

机构信息

Department of Public Health, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.

Department of Psychiatric Nursing, Faculty of Nursing, Beni-Suef University, Beni-Suef, Egypt.

出版信息

PLoS One. 2022 Jun 15;17(6):e0269803. doi: 10.1371/journal.pone.0269803. eCollection 2022.

DOI:10.1371/journal.pone.0269803

PMID:35704613

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9200325/

Abstract

BACKGROUND

The prevalence of autism spectrum disorder (ASD) has been increasing steadily in Egypt and worldwide. Detecting risk factors for ASD could help initiate screening and risk prevention approaches. Herein, this study aimed to detect several maternal and neonatal risk factors for ASD in Egypt.

METHODS

In this case-control study, mothers of children with ASD who were visiting Beni-Suef University Hospital in Egypt (n = 268) were compared to mothers of children without ASD attending one primary school with a kindergarten (n = 504) regarding their preconception, conception, and postconception characteristics. Data were collected using a self-administered questionnaire. The odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to investigate the possible associations between the collected data and the odds of ASD.

RESULTS

In the multivariable-adjusted models, urban residence: OR (95% CI) = 2.33 (1.60-3.38), relative father: 2.63 (1.74-3.96), history of diabetes: 5.98 (1.99-17.97), previous abortion: 2.47 (1.20-13.38), assisted fertility: 4.01 (1.20-13.38), family history of ASD: 7.24 (2.00-26.24), multiple pregnancy: 11.60 (2.54-53.07), exposure to passive smoking during pregnancy: 2.95 (1.86-4.68), vaginal bleeding during pregnancy: 3.10 (1.44-6.67), hypertension with pregnancy: 3.64 (1.06-12.51), preterm labor: 2.64 (1.26-5.57), neonatal convulsions: 14.88 (5.01-44.20), and admission to neonatal intensive care unit 2.13: (1.21-3.74) were associated with the increased odds of ASD. On the other hand, the intake of vitamins during pregnancy: 0.09 (0.06-0.16) and C-section: 0.44 (0.27-0.70) were associated with the decreased odds of ASD.

CONCLUSION

This study detected several maternal and neonatal risk factors for ASD in Egyptian children.

摘要

背景

自闭症谱系障碍 (ASD) 的患病率在埃及和全球范围内持续稳步上升。检测 ASD 的风险因素有助于启动筛查和预防措施。本研究旨在检测埃及 ASD 的几个母婴危险因素。

方法

在这项病例对照研究中，与在埃及 Beni-Suef 大学医院就诊的 ASD 儿童的母亲（n=268）相比，在一所小学就读的无 ASD 儿童的母亲（n=504）比较了她们的孕前、孕期和孕后特征。使用自我管理的问卷收集数据。计算比值比 (OR) 及其 95%置信区间 (CI) 以调查所收集数据与 ASD 发生几率之间的可能关联。

结果

在多变量调整模型中，城市居住：OR（95%CI）=2.33（1.60-3.38），相对父亲：2.63（1.74-3.96），糖尿病史：5.98（1.99-17.97），先前流产：2.47（1.20-13.38），辅助生育：4.01（1.20-13.38），ASD 家族史：7.24（2.00-26.24），多胎妊娠：11.60（2.54-53.07），孕期被动吸烟暴露：2.95（1.86-4.68），孕期阴道出血：3.10（1.44-6.67），孕期高血压：3.64（1.06-12.51），早产：2.64（1.26-5.57），新生儿惊厥：14.88（5.01-44.20），新生儿重症监护病房入院：2.13（1.21-3.74）与 ASD 发生几率增加相关。另一方面，孕期维生素摄入：0.09（0.06-0.16）和剖宫产：0.44（0.27-0.70）与 ASD 发生几率降低相关。