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积极咨询和良好控制的疾病可使更多患有类风湿关节炎的女性进行母乳喂养:PreCARA 研究结果。

Active counselling and well-controlled disease result in a higher percentage of women with rheumatoid arthritis that breast feed: results from the PreCARA study.

机构信息

Erasmus Medical Center, Rotterdam, The Netherlands.

College ter Beoordeling van Geneesmiddelen, Utrecht, The Netherlands.

出版信息

RMD Open. 2022 Jun;8(2). doi: 10.1136/rmdopen-2022-002194.

DOI:10.1136/rmdopen-2022-002194
PMID:35705306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9204414/
Abstract

OBJECTIVES

Previous research has demonstrated that patients with rheumatoid arthritis (RA) are less likely to breast feed their offspring. Treatment options for RA during lactation have expanded and the importance of counselling is recognised. The aim of the current research was to study breast feeding among women with RA who benefit from these developments.

METHODS

Patients were derived from the Preconceptional Counselling in Active Rheumatoid Arthritis (PreCARA) cohort. Patients were treated according to a modified treat-to-target approach aimed at remission and received pregnancy counselling, including counselling on breast feeding. Postpartum visits were scheduled at 4-6, 12 and 26 weeks post partum. Prevalence of breast feeding at each postpartum visit was compared with a historical reference cohort (Pregnancy-induced Amelioration of Rheumatoid Arthritis cohort) and the general population.

RESULTS

Data on 171 pregnancies were available for the current analysis. 120 (70.2%) patients with RA initiated breast feeding. 103/171 (60.2%), 68/171 (39.8%) and 45/171 (26.3%) patients with RA breast fed their offspring at 4-6, 12 and 26 weeks post partum, respectively. These percentages were higher at all postpartum visits compared with the historical reference cohort (p<0.001). In comparison with the general population, the rates were similar at each time point.

CONCLUSION

Patients with RA in the PreCARA cohort were more likely to breast feed their offspring compared with patients with RA in the historical reference cohort. The breastfeeding rates observed were similar to breastfeeding rates among women in the general population. The increase in breast feeding among patients with RA may be due to the extension of lactation-compatible medication and pregnancy counselling.

摘要

目的

先前的研究表明,类风湿关节炎(RA)患者不太可能母乳喂养其后代。哺乳期 RA 的治疗选择已经扩大,并且认识到咨询的重要性。当前研究的目的是研究从这些发展中受益的 RA 患者的母乳喂养情况。

方法

患者来自于孕前主动类风湿关节炎咨询(PreCARA)队列。患者根据旨在缓解的改良治疗目标方法进行治疗,并接受妊娠咨询,包括母乳喂养咨询。产后访视计划在产后 4-6、12 和 26 周进行。每个产后访视的母乳喂养率与历史参考队列(妊娠改善类风湿关节炎队列)和一般人群进行比较。

结果

目前分析可获得 171 例妊娠的数据。120 例(70.2%)RA 患者开始母乳喂养。103/171(60.2%)、68/171(39.8%)和 45/171(26.3%)例 RA 患者分别在产后 4-6、12 和 26 周时母乳喂养其后代。与历史参考队列相比,所有产后访视时的百分比均较高(p<0.001)。与一般人群相比,各时间点的比率相似。

结论

与历史参考队列中的 RA 患者相比,PreCARA 队列中的 RA 患者更有可能母乳喂养其后代。观察到的母乳喂养率与一般人群中女性的母乳喂养率相似。RA 患者母乳喂养率的增加可能是由于延长了哺乳期相容的药物和妊娠咨询。

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The Influence of Treatment of Inflammatory Arthritis During Pregnancy on the Long-Term Children's Outcome.孕期炎症性关节炎的治疗对儿童远期结局的影响
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Modern treatment approach results in low disease activity in 90% of pregnant rheumatoid arthritis patients: the PreCARA study.现代治疗方法使 90%的妊娠类风湿关节炎患者疾病活动度低:PreCARA 研究。
Ann Rheum Dis. 2021 Jul;80(7):859-864. doi: 10.1136/annrheumdis-2020-219547. Epub 2021 Feb 10.
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Disease activity assessment of rheumatic diseases during pregnancy: a comprehensive review of indices used in clinical studies.妊娠期间风湿性疾病的疾病活动评估:临床研究中使用的指标的综合综述。
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