德尔塔和奥密克戎变异株的潜在跨变异和同变异重组。
Potential intervariant and intravariant recombination of Delta and Omicron variants.
机构信息
Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, USA.
Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
出版信息
J Med Virol. 2022 Oct;94(10):4830-4838. doi: 10.1002/jmv.27939. Epub 2022 Jul 9.
Abstract
Among numerous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concerns, Omicron is more infectious and immune-escaping, while Delta is more pathogenic. Here, we provide evidence for both intervariant and intravariant recombination of the rapidly evolving new SARS-CoV-2 genomes, including XD/XE/XF and BA.3, raising concerns of potential more infectious, immune-escaping, and disease-causing Omicron and Delta-Omicron variants.
摘要
在众多令人关注的严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）变体中，奥密克戎的传染性更强且免疫逃避能力更强，而德尔塔则更具致病性。在这里，我们提供了快速进化的新型 SARS-CoV-2 基因组（包括 XD/XE/XF 和 BA.3）在不同变体之间和变体内部发生重组的证据，这引发了人们对潜在更具传染性、免疫逃避能力和致病性的奥密克戎和德尔塔-奥密克戎变体的担忧。
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