Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Department of Neurology, Oslo University Hospital, Oslo, Norway.
Nat Commun. 2022 Jun 15;13(1):3436. doi: 10.1038/s41467-022-31086-w.
Despite its major role in complex human functions across the lifespan, most notably navigation, learning and memory, much of the genetic architecture of the hippocampal formation is currently unexplored. Here, through multivariate genome-wide association analysis in volumetric data from 35,411 white British individuals, we reveal 177 unique genetic loci with distributed associations across the hippocampal formation. We identify genetic overlap with eight brain disorders with typical onset at different stages of life, where common genes suggest partly age- and disorder-independent mechanisms underlying hippocampal pathology.
尽管海马体在人类整个生命周期的复杂功能中扮演着重要角色，尤其是在导航、学习和记忆方面，但它的大部分遗传结构目前仍未被探索。在这里，我们通过对 35411 名英国白人的体积数据进行多变量全基因组关联分析，揭示了 177 个独特的遗传位点，这些位点在海马体中具有分布式关联。我们发现与八种在不同生命阶段发病的脑部疾病存在遗传重叠，其中常见的基因表明，海马体病理的潜在机制在一定程度上与年龄和疾病无关。
