Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, the Netherlands.
NORMENT Centre, University of Oslo, Oslo, Norway.
Nat Genet. 2021 Sep;53(9):1276-1282. doi: 10.1038/s41588-021-00921-z. Epub 2021 Sep 7.
Late-onset Alzheimer's disease is a prevalent age-related polygenic disease that accounts for 50-70% of dementia cases. Currently, only a fraction of the genetic variants underlying Alzheimer's disease have been identified. Here we show that increased sample sizes allowed identification of seven previously unidentified genetic loci contributing to Alzheimer's disease. This study highlights microglia, immune cells and protein catabolism as relevant to late-onset Alzheimer's disease, while identifying and prioritizing previously unidentified genes of potential interest. We anticipate that these results can be included in larger meta-analyses of Alzheimer's disease to identify further genetic variants that contribute to Alzheimer's pathology.
晚发性阿尔茨海默病是一种普遍的与年龄相关的多基因疾病,占痴呆病例的 50-70%。目前,只有一小部分导致阿尔茨海默病的遗传变异已经被确定。在这里,我们展示了增加样本量可以识别出七个以前未被发现的与阿尔茨海默病相关的遗传位点。这项研究强调了小胶质细胞、免疫细胞和蛋白质代谢与晚发性阿尔茨海默病有关,同时确定并优先考虑了以前未被发现的具有潜在重要性的基因。我们预计这些结果可以纳入更大规模的阿尔茨海默病荟萃分析中,以确定更多导致阿尔茨海默病病理的遗传变异。