Program in Public Health, Department of Health, Society, & Behavior, University of California, Irvine, 653 E. Peltason Dr., Anteater Instruction and Research Building (AIRB) 2022, Irvine, CA, 92697-3957, USA.
School of Public Policy, University of Maryland, College Park, MD, USA.
J Racial Ethn Health Disparities. 2023 Aug;10(4):1605-1615. doi: 10.1007/s40615-022-01347-x. Epub 2022 Jun 15.
Studies generally show that higher acculturation is associated with greater cardiovascular disease (CVD) risk among immigrants in the United States (US). However, few studies have compared how proxies of acculturation are differentially associated with metabolic abnormalities measured using objective biomarkers, self-reported diagnosis, and medication use, particularly among East Asian Americans.
Survey data and biomarker measurements collected from random (non-fasting) blood samples of Chinese and Korean immigrants in the US (n = 328) were used to examine the associations between two proxies for acculturation (years living in the US and English speaking proficiency) with three cardiometabolic abnormalities (high triglyceride levels, diabetes, and hypercholesterolemia). Poisson regression models estimated prevalence ratios adjusted for demographic characteristics, socioeconomic factors, and body mass index. Gender, Asian subgroup, and household income were tested as potential effect modifiers.
Living longer in the US was associated with greater likelihood of having high triglycerides. In addition, living longer in the US was associated with greater likelihood of diabetes for people with lower household income and greater likelihood of hypercholesterolemia for people with higher household income. Higher level of English proficiency was less consistently associated with higher cardiometabolic risk, although there was a significant association with greater likelihood of hypercholesterolemia.
Longer time lived in the US is associated with higher risk of cardiometabolic abnormalities among Chinese and Korean Americans. Future studies of acculturation and cardiometabolic risk should carefully consider potential mechanisms and what proxy measures of acculturation capture.
NCT03481296, date of registration: 3/29/2018.
研究表明，在美国，移民的文化融合程度越高，心血管疾病（CVD）的风险就越大。然而，很少有研究比较文化融合的代理指标如何与使用客观生物标志物、自我报告的诊断和药物使用测量的代谢异常相关，特别是在东亚裔美国人中。
使用来自美国华裔和韩裔移民的随机（非空腹）血液样本的调查数据和生物标志物测量值（n=328），研究了文化融合的两个代理指标（在美国生活的年限和英语熟练程度）与三种心血管代谢异常（高甘油三酯水平、糖尿病和高胆固醇血症）之间的关系。泊松回归模型估计了调整人口统计学特征、社会经济因素和体重指数后的患病率比。性别、亚洲亚组和家庭收入被测试为潜在的效应修饰剂。
在美国生活时间越长，患高甘油三酯的可能性越大。此外，对于家庭收入较低的人，在美国生活时间越长，患糖尿病的可能性越大，对于家庭收入较高的人，患高胆固醇血症的可能性越大。较高的英语熟练程度与更高的心血管代谢风险的相关性不太一致，但与更高的高胆固醇血症的可能性有显著相关性。
在美国生活时间越长，华裔和韩裔美国人患心血管代谢异常的风险越高。未来关于文化融合和心血管代谢风险的研究应仔细考虑潜在的机制和文化融合代理指标的捕获。
NCT03481296，注册日期：2018 年 3 月 29 日。
