Xia Jinying, Li Jianhui, Jin Guang, Yao Danzhen, Hua Qifeng
Department of Endocrinology, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, People's Republic of China.
Department of Ultrasound, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, People's Republic of China.
Diabetes Metab Syndr Obes. 2022 Jun 9;15:1749-1759. doi: 10.2147/DMSO.S371208. eCollection 2022.
Patients with non-alcoholic fatty liver disease (NAFLD) are more likely to develop left ventricular diastolic dysfunction (LVDD). Although lifestyle adjustments contribute to the improvement of NAFLD, thereby delaying or even preventing LVDD progression, it is difficult to maintain a healthy lifestyle, resulting in a higher incidence of LVDD in NAFLD patients.
This study aims to develop a nomogram for assessing the risk of LVDD progression in NAFLD patients to increase their adherence to therapeutic interventions and adjust their treatment regimens timely.
A total of 148 medical records of NAFLD patients were retrospectively analyzed. Sixty-three were assigned to the LVDD+ group and 85 were assigned to the LVDD- group. The independent correlates of LVDD, which were screened via least absolute shrinkage and selection operator logistic regression model first, followed by multivariate Logistic regression model, constituted the nomogram to determine the likelihood of LVDD in NAFLD patients.
Number of comorbidities, glycosylated hemoglobin, and epicardial adipose tissue (EAT) volume index were independent correlates of LVDD (all < 0.05). They served as components in the newly developed nomogram. It obtained significant clinical benefit in detecting NAFLD patients at the risk of LVDD progression, with satisfied discrimination and calibration.
We developed a nomogram for identifying NAFLD patients with a normal diastolic function who are at risk of LVDD progression, thus contributing to effective prevention of LVDD progression.
非酒精性脂肪性肝病（NAFLD）患者更易发生左心室舒张功能障碍（LVDD）。尽管生活方式调整有助于改善NAFLD，从而延缓甚至预防LVDD进展，但保持健康的生活方式很困难，导致NAFLD患者中LVDD的发病率较高。
本研究旨在开发一种列线图，用于评估NAFLD患者LVDD进展的风险，以提高他们对治疗干预的依从性，并及时调整治疗方案。
回顾性分析了148例NAFLD患者的病历。63例被分配到LVDD+组，85例被分配到LVDD-组。首先通过最小绝对收缩和选择算子逻辑回归模型，然后通过多变量逻辑回归模型筛选出LVDD的独立相关因素，构成列线图以确定NAFLD患者发生LVDD的可能性。
合并症数量、糖化血红蛋白和心外膜脂肪组织（EAT）体积指数是LVDD的独立相关因素（均P<0.05）。它们作为新开发列线图的组成部分。该列线图在检测有LVDD进展风险的NAFLD患者方面具有显著的临床益处，具有满意的区分度和校准度。
我们开发了一种列线图，用于识别舒张功能正常但有LVDD进展风险的NAFLD患者，从而有助于有效预防LVDD进展。
