Ahmadinasab Haleh, Motaghinejad Majid, Nosratabad Bahareh Arabzadeh, Bozorgniahosseini Seyedehnahal, Rostami Parastoo, Jafarabadi Golbarg Shabani, Motevalian Manijeh
Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.
Chronic Respiratory Disease Research Center(CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Int J Prev Med. 2022 Apr 8;13:65. doi: 10.4103/ijpvm.IJPVM_435_20. eCollection 2022.
As a psychostimulant agent, methylphenidate (MPH) abuse can cause serious liver damage. Studies have documented the hepatoprotective impacts of curcumin on liver damage. According to this definition, the purpose of this study is to explain the hapatoprotective effects of curcumin against the hepatotoxicity induced by MPH.
Seventy rats were equally divided into seven groups (10 rats per group). Groups 1 and 2 received normal saline (0.7 mL/rat) and MPH (10 mg/kg), respectively for 21 days. Groups 3, 4, 5, and 6 concurrently received MPH (10 mg/ kg) and curcumin (10, 20, 40, and 60 mg/kg, respectively) for 21 days. Group 7 was treated with curcumin (60 mg/kg) alone for 21 days. The hepatic function test key enzymes such as AST, ALP, and histology of liver tissue (ALT), and alkaline phosphatase (ALP) levels was studied in the blood samples, and also, the histopathological changes and cell density changes were evaluated in the liver tissue.
The latest studies have shown that the administration of MPH induces rises in the AST, ALT, and ALP levels and induces degeneration changes in histopathology, whereas curcumin administration at doses of 40 and 60 mg/kg reduced the elevation of MPH-induced hepatic enzyme and inhibited histopathological degeneration in the MPH-treated classes. Curcumin alone (60 mg/kg) did not alter the biochemical and histological parameters.
Curcumin can function as a hepatoprotective agent against MPH-induced hepatotoxicity.
作为一种精神兴奋剂，哌醋甲酯（MPH）滥用会导致严重的肝损伤。研究已证明姜黄素对肝损伤具有肝脏保护作用。根据这一定义，本研究的目的是解释姜黄素对MPH诱导的肝毒性的肝脏保护作用。
70只大鼠平均分为7组（每组10只）。第1组和第2组分别接受生理盐水（0.7 mL/只）和MPH（10 mg/kg），持续21天。第3、4、5和6组同时接受MPH（10 mg/kg）和姜黄素（分别为10、20、40和60 mg/kg），持续21天。第7组单独用姜黄素（60 mg/kg）治疗21天。在血液样本中研究肝功能测试关键酶如天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）和碱性磷酸酶（ALP）水平，以及肝组织的组织学情况，并且还评估肝组织中的组织病理学变化和细胞密度变化。
最新研究表明，给予MPH会导致AST、ALT和ALP水平升高，并在组织病理学上引起变性变化，而给予40和60 mg/kg剂量的姜黄素可降低MPH诱导的肝酶升高，并抑制MPH处理组中的组织病理学变性。单独使用姜黄素（60 mg/kg）不会改变生化和组织学参数。
姜黄素可作为一种针对MPH诱导的肝毒性的肝脏保护剂。
