Parisi Silvana, Lillo Sara, Cacciola Alberto, Ferini Gianluca, Valenti Vito, Viola Anna, Santacaterina Anna, Platania Angelo, Brogna Anna, Tamburella Consuelo, Pergolizzi Stefano
Radiation Oncology Unit - Department of Biomedical, Dental Science and Morphological and Functional Images, University of Messina, Messina, Italy.
Radiation Oncology Unit - REM Radioterapia, Viagrande, Italy.
Heliyon. 2022 May 31;8(6):e09593. doi: 10.1016/j.heliyon.2022.e09593. eCollection 2022 Jun.
Old or very old oncological patients represent a heterogeneous and frail population due to concomitant comorbidities. Whether radiotherapy alone or in combination with novel cancer drugs may provide a clear benefit in this setting of patients is still a matter of debate. The aim of our review is to analyze the evaluation process and the different therapeutic possibilities in older cancer patients, focusing on the different and most disparate applications of radiotherapy. We reviewed the most recent literature on radiotherapy in older patients providing clinical evidence of treatment related toxicity, tolerance and outcomes using standard fractionated and/or hypofractionated irradiation alone or in combination with chemotherapy, targeted and immunotherapy. In older cancer patients unfit for systemic therapy or surgery, radiotherapy represents a valid therapeutic approach, both with curative and palliative intents, ensuring excellent patient compliance in terms of local toxicity and adherence to therapy.
由于合并症，老年或高龄肿瘤患者是一个异质性且脆弱的群体。单独放疗或与新型抗癌药物联合放疗在这类患者中是否能带来明显益处仍是一个有争议的问题。我们综述的目的是分析老年癌症患者的评估过程和不同的治疗可能性，重点关注放疗的不同且差异极大的应用。我们回顾了关于老年患者放疗的最新文献，这些文献提供了单独使用标准分割和/或大分割照射或与化疗、靶向治疗和免疫治疗联合使用时与治疗相关的毒性、耐受性和结局的临床证据。对于不适合进行全身治疗或手术的老年癌症患者，放疗是一种有效的治疗方法，具有根治性和姑息性目的，在局部毒性和治疗依从性方面能确保患者有良好的依从性。
