Systems Biology & Medicine Center for Complex Diseases, Center for Clinical Research, Affiliated Hospital of Qingdao University, Qingdao 266003, China.
Department of Pediatrics, Affiliated Hospital of Qingdao University, Qingdao 266003, China.
Oxid Med Cell Longev. 2022 Jun 6;2022:8494076. doi: 10.1155/2022/8494076. eCollection 2022.
The clinical GGT data from 168,858 patients with 44 diseases and 132,357 healthy control in the clinical laboratory of our hospital over the past five years were retrieved. All data were analyzed with SPSS, RStudio V.1.3.1073, and python libraries 3.8.
Thirty-eight out of 44 diseases had significantly increased ( < 0.001) circulating GGT activities, whereas gastric cancer, anemia, renal cyst, cervical cancer, preeclampsia, and knee-joint degenerative diseases had significantly decreased ( < 0.001) GGT activities compared to the healthy control. ROC analyses showed that GGT was an excellent biomarker for liver cancer (AUC = 0.86), pancreatitis (AUC = 0.84), or hepatic encephalopathy (AUC = 0.80). All pancreas-related diseases had more than 8-fold increases in GGT activity span than the healthy control, while pancreatic cancer had a 12-fold increase (1021 U/L vs. 82 U/L). The knee-joint degenerative disease had the lowest median and narrowest GGT activity range (63 U/L). Furthermore, most diseases' lowest to highest GGT activities were beyond the healthy control in both directions.
Thirty-eight out of 44 diseases were in overall oxidative states defined by the increased GGT median values. In contrast, knee-joint degenerative disease, gastric cancer, anemia, renal cyst, cervical cancer, and preeclampsia were in overall antioxidative states. Moreover, most diseases swing between oxidative and antioxidative states, evidenced by the increased lowest to highest GGT activity ranges than the healthy control. Liver- and pancreas-related abnormalities were responsible for significantly increased GGT activities. Our overall results suggested that circulating GGT was a redox status biomarker.
回顾了过去五年我院临床实验室 168858 例 44 种疾病和 132357 例健康对照患者的临床 GGT 数据。所有数据均采用 SPSS、RStudio V.1.3.1073 和 python 库 3.8 进行分析。
与健康对照组相比，44 种疾病中有 38 种疾病的循环 GGT 活性显著升高（<0.001），而胃癌、贫血、肾囊肿、宫颈癌、子痫前期和膝关节退行性疾病的 GGT 活性显著降低（<0.001）。ROC 分析表明，GGT 是肝癌（AUC=0.86）、胰腺炎（AUC=0.84）或肝性脑病（AUC=0.80）的优秀生物标志物。所有胰腺相关疾病的 GGT 活性跨度均超过健康对照组的 8 倍，而胰腺癌则增加了 12 倍（1021 U/L 比 82 U/L）。膝关节退行性疾病的中位数最低，GGT 活性范围最窄（63 U/L）。此外，大多数疾病的最低到最高 GGT 活性在两个方向上均超过健康对照组。
44 种疾病中有 38 种疾病的 GGT 中位数增加，总体处于氧化状态。相比之下，膝关节退行性疾病、胃癌、贫血、肾囊肿、宫颈癌和子痫前期处于总体抗氧化状态。此外，大多数疾病在氧化和抗氧化状态之间波动，这表现为增加的最低到最高 GGT 活性范围超过健康对照组。肝和胰腺相关异常是导致 GGT 活性显著增加的原因。我们的总体结果表明，循环 GGT 是一种氧化还原状态的生物标志物。
