Kocaaga Ayca, Kocaaga Mustafa
Department of Medical Genetics, Eskişehir City Hospital, Eskisehir, Turkey.
Department of Medical Microbiology, Yunus Emre State Hospital, Eskisehir, Turkey.
Glob Med Genet. 2022 Jun 13;9(2):82-89. doi: 10.1055/s-0042-1743259. eCollection 2022 Jun.
Psoriasis is an erythematous-squamous dermatosis with a polygenic inheritance history. Both environmental and genetic factors play a role in the etiology of the disease. Over the past two decades, numerous linkage analyzes and genome-wide association studies have been conducted to investigate the role of genetic variation in disease pathogenesis and progression. To date, >70 psoriasis susceptibility loci have been identified, including HLA-Cw6, IL12B, IL23R, and LCE3B/3C. Some genetic markers are used in clinical diagnosis, prognosis, treatment, and personalized new drug development that can further explain the pathogenesis of psoriasis. This review summarizes the immunological mechanisms involved in the etiopathogenesis of psoriasis and recent advances in susceptibility genes and highlights new potential targets for therapeutic intervention.
银屑病是一种具有多基因遗传史的红斑鳞屑性皮肤病。环境因素和遗传因素在该疾病的病因中均起作用。在过去二十年中，已经进行了大量的连锁分析和全基因组关联研究，以调查基因变异在疾病发病机制和进展中的作用。迄今为止，已鉴定出>70个银屑病易感基因座，包括HLA-Cw6、IL12B、IL23R和LCE3B/3C。一些基因标志物用于临床诊断、预后、治疗和个性化新药开发，这可以进一步解释银屑病的发病机制。本综述总结了银屑病发病机制中涉及的免疫机制以及易感基因的最新进展，并强调了治疗干预的新潜在靶点。
