Department of Dermatology, School of Medicine, Kutahya Health Sciences University, Kutahya, Turkey,
Department of Physiology, School of Medicine, Kutahya Health Sciences University, Kutahya, Turkey.
Skin Pharmacol Physiol. 2020;33(6):317-322. doi: 10.1159/000512124. Epub 2020 Dec 18.
Psoriasis known as a chronic inflammatory skin disease is accompanied by metabolic disorders such as obesity, diabetes, and dyslipidemia. Vaspin (a serine protease inhibitor derived from visceral adipose tissue) is a newly identified adipokine and a link between inflammation and obesity has been reported. We aimed to determine whether vaspin gene polymorphism is associated with the development and/or clinical features of psoriasis vulgaris.
Our study group consisted of 96 psoriasis vulgaris patients and 100 matched controls. Vaspin rs2236242 gene was genotyped using PCR.
The vaspin genotypes showed a meaningful difference between psoriasis and control groups (p = 0.02). The frequency of the vaspin rs2236242 TT genotype was lower in psoriasis patients than in control participants (p < 0.05). The TA genotype was associated with a 2.38-fold increased risk of psoriasis compared to the TT genotype (p = 0.007, odds ratio: 2.38; 95% confidence interval: 1.25-4.55), but not the AA genotype. All subjects were the Turkish population, the study in other populations is needed and the sample size was small in number.
Our study demonstrated that vaspin rs2236242 polymorphism is related to psoriasis in the Turkish population. Polymorphisms of the vaspin gene might serve as diagnostic biomarkers of psoriasis.
银屑病是一种慢性炎症性皮肤病，常伴有肥胖、糖尿病和血脂异常等代谢紊乱。内脏脂肪组织衍生的丝氨酸蛋白酶抑制剂（vaspin）是一种新发现的脂肪因子，炎症与肥胖之间的联系已被报道。我们旨在确定 vaspin 基因多态性是否与寻常型银屑病的发生和/或临床特征有关。
我们的研究组包括 96 例寻常型银屑病患者和 100 例匹配对照。采用 PCR 法对 vaspin rs2236242 基因进行基因分型。
银屑病组和对照组之间 vaspin 基因型存在显著差异（p = 0.02）。银屑病患者 vaspin rs2236242 TT 基因型的频率低于对照组（p < 0.05）。与 TT 基因型相比，TA 基因型患银屑病的风险增加了 2.38 倍（p = 0.007，优势比：2.38；95%置信区间：1.25-4.55），但 AA 基因型没有。所有受试者均为土耳其人群，需要在其他人群中进行研究，且样本量较小。
本研究表明，vaspin rs2236242 多态性与土耳其人群的银屑病有关。vaspin 基因多态性可能可作为银屑病的诊断生物标志物。
