Department of ophthalmology, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.
Ocul Immunol Inflamm. 2023 Jul;31(5):999-1005. doi: 10.1080/09273948.2022.2080719. Epub 2022 Jun 16.
To investigate the features of macrophage-like cell (MLC) characterized by en face optical coherence tomography (OCT) in Behçet's uveitis (BU).
The extent of fluorescein vascular leakage (FVL) was graded on a scale of 0-3 (0=none, 1=mild, 2=moderate, 3=severe) for the optic nerve head (ONH), macula and peripheral retina. The 3μm en face OCT slabs on inner limiting membrane of ONH or macular region was used to visualize the MLCs.
The MLC densities of BU group in ONH and macular region were significantly higher than the control group (both p<0.001). The ONH and macular MLC density were significantly higher in eyes with higher FVL grade and they were positively correlated with FVL score (all p<0.001).
MLC density was elevated in Behçet's uveitis and it may serve as a noninvasive indicator for the severity of fluorescein leakage and retinal inflammation in Behcet's uveitis.
探讨 Behcet 葡萄膜炎（BU）中经眼前节光学相干断层扫描（OCT）特征化的巨噬细胞样细胞（MLC）的特点。
视神经头（ONH）、黄斑和周边视网膜的荧光素血管渗漏（FVL）程度按 0-3 级（0=无，1=轻度，2=中度，3=重度）分级。使用 3μm 眼前节 OCT 切片在内界膜上观察 ONH 或黄斑区域的 MLC。
BU 组 ONH 和黄斑区的 MLC 密度明显高于对照组（均 p<0.001）。FVL 分级较高的眼的 ONH 和黄斑 MLC 密度明显较高，且与 FVL 评分呈正相关（均 p<0.001）。
MLC 密度在 Behcet 葡萄膜炎中升高，可能作为 Behcet 葡萄膜炎中荧光素渗漏和视网膜炎症严重程度的非侵入性指标。
