Kim Jungwoo, Ju Jaewon, Kim Sung Dong, Shin Mikyung
Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea.
Department of Biomedical Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea.
Biomater Sci. 2022 Jul 12;10(14):3739-3746. doi: 10.1039/d2bm00630h.
Polymeric micelles are the most common carriers used for hydrophobic drug delivery. However, they are vulnerable to physiological barriers, such as temperature changes and enzymatic degradation, and can be easily disassembled upon dilution below the critical micelle concentration (CMC) by body fluids after an intravenous injection. Here, we report that Pluronic® micelles with octyl gallate, which is a surfactant containing gallol moieties widely found in antioxidative plant polyphenols, have a low CMC, which improves their colloidal stability without the need for covalent crosslinking. Furthermore, the incorporated gallol moieties provide enzymatic degradation resistance to the micelles owing to their protein affinity, maintaining the hydrophobic cavity of unmodified Pluronic®. Thus, plant-inspired polymeric micelles with low CMC and bioavailability are promising multifunctional vehicles for drug delivery.
聚合物胶束是用于疏水性药物递送的最常见载体。然而，它们易受生理屏障的影响，如温度变化和酶降解，并且在静脉注射后，当被体液稀释至低于临界胶束浓度（CMC）时，它们很容易解体。在此，我们报道了含有没食子酸辛酯的普朗尼克®胶束，没食子酸辛酯是一种含有广泛存在于抗氧化植物多酚中的没食子醇部分的表面活性剂，其临界胶束浓度较低，无需共价交联即可提高其胶体稳定性。此外，由于没食子醇部分与蛋白质的亲和力，并入的没食子醇部分赋予胶束抗酶降解能力，保持了未修饰普朗尼克®的疏水腔。因此，具有低临界胶束浓度和生物利用度的受植物启发的聚合物胶束是很有前景的多功能药物递送载体。
