Hwang Juyoung, Park Ji Yeong, Kang Jio, Oh Nuri, Li Chen, Yoo Chung-Yul, Um Wooram, Kwak Minseok
Department of Chemistry and Industry 4.0 Convergence Bionics Engineering, Pukyong National University, 45 Yongso-Ro, Nam-Gu, Busan, 48513, Republic of Korea.
Smart Gym-based Translational Research Center for Active Senior's Healthcare, Pukyong National University, 45 Yongso-Ro, Nam-Gu, Busan, 48513, Republic of Korea.
Macromol Rapid Commun. 2024 Dec;45(24):e2400480. doi: 10.1002/marc.202400480. Epub 2024 Jul 31.
In this study, oil-in-water nanoemulsions are prepared, an isotropic mixture of oil, surfactant, and cosurfactants. The nanoemulsions exhibit stable structures and are capable of efficiently encapsulating hydrophobic drugs such as doxorubicin (Dox). Compared to polymeric micelles, nanoemulsions demonstrate enhanced stability and loading capacity for Dox. Furthermore, nanoemulsions release Dox steadily over 14 days, with 51.6% released within the initial 24 h and up to 80% over the subsequent period. These properties suggest that nanoemulsions can mitigate the side effects related to the burst release of Dox, thereby improving therapeutic efficacy and safety. Additionally, nanoemulsion-treated cardiomyocytes show increased viability compared to those treated with free Dox, indicating the potential of nanoemulsions to alleviate Dox-induced cardiotoxicity. Overall, nanoemulsions hold promise as versatile and efficient drug carriers for improving cancer treatment outcomes.
在本研究中，制备了水包油纳米乳液，它是油、表面活性剂和助表面活性剂的各向同性混合物。纳米乳液呈现出稳定的结构，并且能够有效地包封疏水性药物，如阿霉素（Dox）。与聚合物胶束相比，纳米乳液对Dox表现出更高的稳定性和载药量。此外，纳米乳液在14天内稳定释放Dox，最初24小时内释放51.6%，在随后的时间段内释放高达80%。这些特性表明，纳米乳液可以减轻与Dox突发释放相关的副作用，从而提高治疗效果和安全性。此外，与用游离Dox处理的心肌细胞相比，经纳米乳液处理的心肌细胞活力增加，表明纳米乳液具有减轻Dox诱导的心脏毒性的潜力。总体而言，纳米乳液有望成为改善癌症治疗效果的通用且高效的药物载体。
