United Nations Children's Fund (UNICEF), Health Programme, New York, New York, United States of America.
Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, United States of America.
PLoS One. 2022 Jun 16;17(6):e0269063. doi: 10.1371/journal.pone.0269063. eCollection 2022.
At the end of 2019, there were about 2.8 million children and adolescents aged 0-19 living with HIV. In contrast to pregnant women and adults, service delivery for children and adolescents living with HIV continues to lag behind with regard to access to care, components of care delivery, treatment options, and clinical and immunologic outcomes.
The aim of this systematic review is to synthesize the evidence on the most effective interventions, models, programs, and strategies to optimize the delivery of services for the testing, linkage, treatment and retention of children and adolescents living with HIV globally.
This review protocol is registered at PROSPERO with Registration number: CRD42020209553. The systematic review will be conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols (PRISMA-P). We will use a comprehensive search strategy to search several bibliographic databases including MEDLINE, Embase, CINAHL, Cochrane Library, Global Health, and Psycinfo to identify relevant studies published in the last ten years (2010 to 2020). In addition, we will review cited and citing references of included studies. A pair of reviewers will independently screen titles, abstracts and full texts of articles, extract data from articles meeting inclusion criteria and perform quality assessments of the evidence collected. We will conduct a narrative synthesis of our findings, and if there are sufficient clinically similar studies available, we will conduct meta-analysis using a random-effects model.
This review will provide evidence on service delivery models that have been evaluated in a range of settings to efficiently and effectively locate, link, treat and retain in care, children and adolescents living with HIV. The synthesized evidence will help guide national governments and health care providers in prioritizing and adopting evidence-based service delivery approaches for children and adolescents living with HIV.
PROSPERO CRD42020209553.
截至 2019 年底，约有 280 万 0-19 岁的儿童和青少年感染了艾滋病毒。与孕妇和成年人不同，儿童和青少年艾滋病毒感染者的服务提供在获得护理、护理提供的组成部分、治疗选择以及临床和免疫结果方面仍然滞后。
本系统评价的目的是综合全球范围内最有效的干预措施、模式、方案和战略的证据，以优化儿童和青少年艾滋病毒感染者的检测、联系、治疗和保留服务的提供。
本综述方案在 PROSPERO 注册，注册号为：CRD42020209553。系统评价将按照系统评价和荟萃分析报告标准（PRISMA-P）进行。我们将使用全面的检索策略来搜索几个文献数据库，包括 MEDLINE、Embase、CINAHL、 Cochrane 图书馆、全球卫生和 Psycinfo，以确定过去十年（2010-2020 年）发表的相关研究。此外，我们还将审查纳入研究的引用和被引参考文献。一对审查员将独立筛选文章的标题、摘要和全文，从符合纳入标准的文章中提取数据，并对收集的证据进行质量评估。我们将对研究结果进行叙述性综合分析，如果有足够数量的临床相似研究可用，我们将使用随机效应模型进行荟萃分析。
本综述将提供在各种环境中评估的服务提供模式的证据，这些模式旨在有效地定位、联系、治疗和留住儿童和青少年艾滋病毒感染者。综合证据将有助于指导各国政府和医疗保健提供者为儿童和青少年艾滋病毒感染者确定和采用基于证据的服务提供方法。
PROSPERO CRD42020209553。
