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正反方辩论:在舒更葡糖钠时代,我们是否需要定量神经肌肉监测?

Pro-Con Debate: Do We Need Quantitative Neuromuscular Monitoring in the Era of Sugammadex?

机构信息

From the Department of Anaesthesiology and Intensive Care Medicine, School of Medicine, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany.

Department of Anaesthesiology and Intensive Care Medicine, Faculty of Medicine, University of Ulm, Ulm, Germany.

出版信息

Anesth Analg. 2022 Jul 1;135(1):39-48. doi: 10.1213/ANE.0000000000005925. Epub 2022 Jun 16.

Abstract

In this Pro-Con article, we debate the merits of using quantitative neuromuscular blockade monitoring. Consensus guidelines recommend their use to guide the administration of nondepolarizing neuromuscular blockade and reversal agents. A major impediment to this guideline is that until recently, reliable quantitative neuromuscular blockade monitors have not been widely available. Without them, anesthesia providers have been trained with and are adept at using a variety of qualitative neuromuscular blockade monitors otherwise known as peripheral nerve stimulators. Although perhaps less accurate, anesthesia providers find them reliable and easy to use. They have a long track record of using them with the perception that their use leads to effective neuromuscular blockade reversal and minimizes clinically significant adverse events from residual neuromuscular blockade. In the recent past, 2 disruptive developments have called upon anesthesia care providers to reconsider their practice in neuromuscular blockade administration, reversal, and monitoring. These include: (1) commercialization of more reliable quantitative neuromuscular monitors and (2) widespread use of sugammadex, a versatile reversal agent of neuromuscular blockade. Sugammadex appears to be so effective at rapidly and effectively reversing even the deepest of neuromuscular blockades, and it has left anesthesia providers wondering whether quantitative monitoring is indeed necessary or whether conventional, familiar, and less expensive qualitative monitoring will suffice? This Pro-Con debate will contrast anesthesia provider perceptions with evidence surrounding the use of quantitative neuromuscular blockade monitors to explore whether quantitative neuromuscular monitoring (NMM) is just another technology solution looking for a problem or a significant advance in NMM that will improve patient safety and outcomes.

摘要

在这篇赞成方与反对方的文章中,我们就使用量化神经肌肉阻滞监测的优点展开辩论。共识指南建议使用它来指导非去极化神经肌肉阻滞和逆转剂的给药。这一指南的一个主要障碍是,直到最近,可靠的量化神经肌肉阻滞监测器还没有广泛应用。没有这些监测器,麻醉提供者接受的培训是使用各种定性神经肌肉阻滞监测器,也就是外周神经刺激器,并且已经熟练掌握了这些监测器的使用方法。尽管可能不太准确,但麻醉提供者发现它们可靠且易于使用。他们长期以来一直使用这些监测器,认为它们可以有效地逆转神经肌肉阻滞,并最大限度地减少残留神经肌肉阻滞引起的临床显著不良事件。在最近,有两个突破性的发展促使麻醉护理提供者重新考虑他们在神经肌肉阻滞管理、逆转和监测方面的实践。这些发展包括:(1) 更可靠的量化神经肌肉监测器的商业化,以及 (2) 神经肌肉阻滞逆转剂罗库溴铵的广泛应用。罗库溴铵似乎非常有效地迅速有效地逆转即使是最深的神经肌肉阻滞,这让麻醉提供者怀疑量化监测是否真的有必要,或者传统的、熟悉的、成本较低的定性监测是否就足够了?这场赞成方与反对方的辩论将对比麻醉提供者的看法与量化神经肌肉阻滞监测使用相关的证据,以探讨量化神经肌肉监测(NMM)是否只是另一种寻求问题解决方案的技术,或者它是否是 NMM 的一个重大进展,将提高患者的安全性和治疗效果。

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