Choovuthayakorn Janejit, Chokesuwattanaskul Susama, Phinyo Phichayut, Hansapinyo Linda, Pathanapitoon Kessara, Chaikitmongkol Voraporn, Watanachai Nawat, Kunavisarut Paradee, Patikulsila Direk
Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Cornea and Refractive Surgery Unit, Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Ophthalmic Res. 2022;65(6):668-677. doi: 10.1159/000525512. Epub 2022 Jun 16.
The study aimed to determine a reference database of the thickness and intraocular thickness asymmetry of total retina, retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and inner plexiform layer (IPL) in healthy Thai subjects measured by the Spectralis spectral-domain optical coherence tomography.
This cross-sectional study recruited the healthy subjects age ≥18 years, having spherical refraction within ±6 diopters and cylindrical refraction ±3 diopters, from a hospital's personnel and the people visiting the ophthalmology department. Only 1 eye of each subject was randomly selected for an analysis. Macular images were obtained using posterior pole thickness scan protocol over a 24° × 24° area at the center of the fovea. The automated retinal thickness segmentation values of total retina and three inner retinal layers were calculated for the mean and the mean intraocular thickness difference between superior and inferior retinal hemispheres. The influence of age, gender, and axial length on thickness and thickness asymmetry of individualized retinal layer was evaluated.
252 subjects were included in study with a mean (SD) age of 46.7 (15.8) years, and 120 (47.6%) were males. According to the Early Treatment Diabetic Retinopathy Study map, the inner ring area was the thickest location of the total retina (range; 326.0-341.5 µm), GCL (range; 47.7-52.7 µm), and IPL (range; 39.9-42.1 µm), whereas the thickest location of RNFL was at the outer ring area (range; 18.8-47.5 µm). For posterior pole intraocular thickness asymmetry, the greatest mean ± SD difference was observed for total retina (9.0 ± 2.2 µm), followed by RNFL (9.9 ± 3.2 µm) and GCL (2.7 ± 0.6 µm), and the lowest mean difference was noted for IPL (2.4 ± 0.5 µm). The thickness and thickness asymmetry of each retinal layer were variably influenced by age, gender, and axial length; however, these factors had a minimal influence on the thickness asymmetry maps of GCL and RNFL.
The reference database of the macular thickness and thickness asymmetry from this study would be beneficial in determining physiologic variations of the OCT parameters in the healthy Thai population.
本研究旨在通过Spectralis光谱域光学相干断层扫描技术确定健康泰国受试者的全视网膜、视网膜神经纤维层（RNFL）、神经节细胞层（GCL）和内网状层（IPL）厚度及眼内厚度不对称性的参考数据库。
这项横断面研究招募了年龄≥18岁、球镜屈光度在±6屈光度以内且柱镜屈光度在±3屈光度以内的健康受试者，受试者来自医院工作人员和眼科门诊患者。每位受试者仅随机选取1只眼进行分析。使用后极厚度扫描协议在黄斑中心凹24°×24°区域获取黄斑图像。计算全视网膜和三个视网膜内层的自动视网膜厚度分割值的平均值以及视网膜上下半球之间的平均眼内厚度差异。评估年龄、性别和眼轴长度对个体化视网膜层厚度和厚度不对称性的影响。
252名受试者纳入研究，平均（标准差）年龄为46.7（±15.8）岁，男性120名（47.6%）。根据糖尿病视网膜病变早期治疗研究图谱，内环区域是全视网膜（范围：326.0 - 341.5 µm）、GCL（范围：47.7 - 52.7 µm）和IPL（范围：39.9 - 42.1 µm）最厚的部位，而RNFL最厚的部位在外环区域（范围：18.8 - 47.5 µm）。对于后极眼内厚度不对称性，全视网膜观察到的平均±标准差差异最大（9.0 ± 2.2 µm），其次是RNFL（9.9 ± 3.2 µm）和GCL（2.7 ± 0.6 µm），IPL的平均差异最小（2.4 ± 0.5 µm）。各视网膜层的厚度和厚度不对称性受年龄、性别和眼轴长度的影响各不相同；然而，这些因素对GCL和RNFL的厚度不对称性图谱影响最小。
本研究的黄斑厚度和厚度不对称性参考数据库将有助于确定健康泰国人群中光学相干断层扫描参数的生理变异。
