Russell R W, Reed R B
J Anim Sci. 1987 Apr;64(4):1010-8. doi: 10.2527/jas1987.6441010x.
A model of the kinetics of water metabolism is not synonymous with an anatomic model of body water pools. Quantitating the anatomic relations of pools of body water that are separable on a kinetic basis is very difficult, and these relations are influenced by the physiological state of the animal. A fifteen-pool, flow-limited simulation model of body water distribution and mixing was constructed based on literature values to study the relationship between anatomical and kinetic pools of body water. The blood dilution curve predicted by the model agrees well with dilution curves in the literature. Altering rumen water volume in the model does not alter the blood dilution curve. Segmenting anatomical pools of water on the basis of blood deuterium oxide (D2O) dilution curves is not a realistic goal. Total body water, independent of the physiological state of the animal, can be measured by D2O dilution after isotopic equilibration has been established if corrections are made for the amount of D2O that is lost prior to attaining equilibrium. The model can be used to search for dosing and sampling schemes that have the potential for fractionating anatomical pools of body water. Although the model is not predictive of any particular situation, it does provide a good base for researching kinetics of body water distribution and body composition.
水代谢动力学模型并非等同于身体水池的解剖学模型。定量基于动力学可分离的身体水池的解剖学关系非常困难，并且这些关系受动物生理状态的影响。基于文献值构建了一个十五水池、流量受限的身体水分布和混合模拟模型，以研究身体水的解剖学和动力学水池之间的关系。该模型预测的血液稀释曲线与文献中的稀释曲线吻合良好。在模型中改变瘤胃水量不会改变血液稀释曲线。基于血液氧化氘（D2O）稀释曲线对解剖学水池进行细分并非现实目标。如果对达到平衡之前损失的D2O量进行校正，那么在建立同位素平衡后，可通过D2O稀释法测量与动物生理状态无关的总体水含量。该模型可用于寻找有可能对身体水的解剖学水池进行分级的给药和采样方案。尽管该模型不能预测任何特定情况，但它确实为研究身体水分布动力学和身体成分提供了一个良好的基础。
